A case of treatment related death caused by mucosal necrosis, brain necrosis and osteonecrosis after carbon ion radiotherapy in nasopharyngeal adenoid cystic carcinoma

Q4 Medicine
Yusuke Nakata, Y. Demizu, T. Okimoto, Takeshi Shimizu
{"title":"A case of treatment related death caused by mucosal necrosis, brain necrosis and osteonecrosis after carbon ion radiotherapy in nasopharyngeal adenoid cystic carcinoma","authors":"Yusuke Nakata, Y. Demizu, T. Okimoto, Takeshi Shimizu","doi":"10.5981/JJHNC.47.71","DOIUrl":null,"url":null,"abstract":"A 41-year old man with nasopharyngeal adenoid cystic carcinoma (T4aN0M0) received carbon ion radiotherapy of 65 Gy (RBE) in 25 fractions. The treatment was well tolerated and complete response was obtained. At 30 months after the therapy, mucosal necrosis and brain necrosis were observed as a late toxicity. Despite treatment with oral steroid, brain necrosis worsened and osteonecrosis of the skull base and cervical spine was newly observed. The patient died of intracranial infection caused by mucosal necrosis, brain necrosis and osteonecrosis of the skull base and cervical spine at 54 months after the carbon ion radiotherapy. A pathological au-topsy revealed no recurrence of adenoid cystic carcinoma. Carbon ion radiotherapy may be a useful treatment option for radioresistant malignant tumors of the head and neck. Optimal treatment planning and long-term careful follow-up are necessary to control fatal late toxicities.","PeriodicalId":38497,"journal":{"name":"Japanese Journal of Head and Neck Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese Journal of Head and Neck Cancer","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5981/JJHNC.47.71","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

A 41-year old man with nasopharyngeal adenoid cystic carcinoma (T4aN0M0) received carbon ion radiotherapy of 65 Gy (RBE) in 25 fractions. The treatment was well tolerated and complete response was obtained. At 30 months after the therapy, mucosal necrosis and brain necrosis were observed as a late toxicity. Despite treatment with oral steroid, brain necrosis worsened and osteonecrosis of the skull base and cervical spine was newly observed. The patient died of intracranial infection caused by mucosal necrosis, brain necrosis and osteonecrosis of the skull base and cervical spine at 54 months after the carbon ion radiotherapy. A pathological au-topsy revealed no recurrence of adenoid cystic carcinoma. Carbon ion radiotherapy may be a useful treatment option for radioresistant malignant tumors of the head and neck. Optimal treatment planning and long-term careful follow-up are necessary to control fatal late toxicities.
鼻咽腺样囊性癌碳离子放疗后黏膜坏死、脑坏死、骨坏死致治疗相关性死亡1例
41岁男性鼻咽腺样囊性癌(T4aN0M0)接受25次65 Gy的碳离子放射治疗。治疗耐受性良好,完全缓解。治疗30个月后出现黏膜坏死和脑坏死的晚期毒性反应。尽管口服类固醇治疗,脑坏死恶化,颅底和颈椎骨坏死新发现。患者于碳离子放疗后54个月死于颅底及颈椎粘膜坏死、脑坏死及骨坏死所致颅内感染。病理解剖显示腺样囊性癌未复发。碳离子放射治疗可能是头颈部放射耐药恶性肿瘤的有效治疗选择。最佳的治疗计划和长期仔细的随访是控制致命的晚期毒性的必要条件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Japanese Journal of Head and Neck Cancer
Japanese Journal of Head and Neck Cancer Medicine-Otorhinolaryngology
CiteScore
0.10
自引率
0.00%
发文量
7
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信