A retrospective study on adverse obstetric outcomes in HIV-infected pregnancy in West Bengal, India

IF 0.3 Q4 INFECTIOUS DISEASES
S. Ganguly, Debjit Chakraborty, D. N. Goswami
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引用次数: 0

Abstract

Introduction: Human immunodeficiency virus (HIV) does not change the course of pregnancy, but seems to exert adverse obstetric outcomes like low birth weight, spontaneous abortion, or stillbirth. Antiretroviral treatment seems to reduce the chance of adverse outcomes. Frequently, HIV-infected women also seems to opt for medical termination of pregnancy (MTP). This study is to compare adverse obstetric outcomes and MTP rate for HIV-infected pregnancy with that in the general population irrespective of antiretroviral treatment (ART). Material and methods: A retrospective cohort study was carried out through analysis of secondary data from 314 integrated counselling and testing centers across the state of West Bengal from October 2016 to December 2017. A total number of 227 HIV-infected on ART pregnancies, whose obstetric outcomes happened during the study period were followed up, and rate for low birth weight, spontaneous abortion, stillbirth, and MTP were calculated, and it was compared with still birth rate of the state among all pregnancies as per data of the District Level Household Survey 4 from 2013. Results: Rates for low birth weight (28.04 per 100 pregnancy outcomes), spontaneous abortion (4.85 per 100), stillbirth (2.64 per 100), and MTP (9.25 per 100 live birth) were found to be significantly high for HIV-infected pregnancies on ART, as compared to the general population. MTP rates and low birth weight rates for general pregnancies did not fall within the 95% confidence interval of those rates for HIV-infected pregnancies. Conclusion: HIV infection was responsible for significant adverse obstetric outcome irrespective of antiretroviral treatment. HIV AIDS Rev 2020; 19, 1: 39-42 DOI: https://doi.org/10.5114/hivar.2020.93189
印度西孟加拉邦艾滋病毒感染妊娠的不良产科结局回顾性研究
人类免疫缺陷病毒(HIV)不会改变妊娠过程,但似乎会产生不良的产科结果,如低出生体重、自然流产或死胎。抗逆转录病毒治疗似乎减少了不良后果的机会。感染艾滋病毒的妇女似乎也经常选择医学终止妊娠。这项研究是为了比较艾滋病毒感染妊娠的不良产科结局和MTP率与一般人群的情况,而不考虑抗逆转录病毒治疗(ART)。材料和方法:通过分析2016年10月至2017年12月来自西孟加拉邦314个综合咨询和测试中心的二手数据,进行了一项回顾性队列研究。对研究期间发生的抗逆转录病毒治疗妊娠中感染艾滋病毒的227例产妇进行随访,计算低出生体重率、自然流产率、死产率和中期分娩率,并根据2013年以来区级住户调查4的数据,将其与该州所有妊娠中的死产率进行比较。结果:与一般人群相比,接受抗逆转录病毒治疗的艾滋病毒感染孕妇的低出生体重率(28.04 / 100个妊娠结局)、自然流产率(4.85 / 100)、死产率(2.64 / 100)和MTP率(9.25 / 100个活产)显著较高。一般妊娠的MTP率和低出生体重率未落在艾滋病毒感染妊娠率的95%置信区间内。结论:无论抗逆转录病毒治疗如何,艾滋病毒感染都是导致显著不良产科结果的原因。艾滋病Rev 2020;[j] .中南大学学报(自然科学版),19 (1):39-42 DOI: https://doi.org/10.5114/hivar.2020.93189
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来源期刊
HIV & AIDS Review
HIV & AIDS Review INFECTIOUS DISEASES-
CiteScore
0.50
自引率
0.00%
发文量
30
审稿时长
12 weeks
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