Impact of Copper Oxide and Selenium Nanoparticles on the Activities of Myeloperoxidase and Gamma-Glutamyl Transferase Related Oxidative Stress of Myocardial Infarction Patients

Abstract

Nanomedicine has tremendous prospects for the improvement of the diagnosis and treatment of human diseases. Nanotechnology has the potential to revolutionize a wide array of tools in biotechnology so that they are more personalized, portable, cheaper, safer and easier to administer. The present study aims to study the impact of copper oxide and selenium nanoparticles on the oxidative stress in sera of myocardial infraction patients through the synthesis and characterization of copper oxide and selenium nanoparticles, and the evaluation of the status of oxidative stress in sera of myocardial infraction patients through measurement of the activities of myeloperoxidase and gammaglutamyl transferase in the presence and absence of nanoparticles in sera of myocardial infraction patients. Cupric oxide nanoparticles and selenium nanoparticles have been prepared by a chemical method and by laser ablation method respectively, and have been characterized. The result indicated that copper oxide (grain shapes with the average size 30 80 nm) and selenium nanoparticles (rodshaped structures with the average size 70 90 nm) had an inhibition effects on myeloperoxidase and gamma-glutamyl transferase activities, and as a result had an inhibition effects on oxidative stress.