Sustained Lower Incidence of Thyroid Cancer in West Cumbria, UK

Journal of thyroid disorders & therapy Pub Date : 2015-07-16 DOI:10.4172/2167-7948.1000187

L. Jonker

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引用次数: 1

Abstract

Background: In recent years, incidences of thyroid cancer have increased in developed countries; one of the known risk factors for thyroid cancer is exposure to radioiodine. Previous research by Bowlt and Tiplady [5] has shown an inverse link between radioactive iodine levels contained in thyroid tissue of deceased inhabitants and the distance they lived from the Sellafield nuclear facility in Cumbria, UK. Objectives: The present study aimed to determine what thyroid cancer incidences were in the regional localities in Cumbria for the last decade. Methods: An ethics-approved retrospective cohort study in which age-standardised incidence of thyroid cancer per 100,000 population was compared between localities within Cumbria and with UK average figures. Conclusions: The present study shows that the apparent lower incidence of thyroid cancer in West Cumbria has persisted, although due to the limited number of thyroid cancers diagnosed, a statistically significant difference was not observed. Further research – potentially involving populations living near sources of radioiodine emission - is indicated to investigate if there are any mechanisms that underlie this apparent trend.

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英国西坎布里亚郡甲状腺癌的持续低发病率

背景:近年来，发达国家甲状腺癌的发病率有所上升;甲状腺癌的已知危险因素之一是暴露于放射性碘。鲍尔特和蒂普拉迪先前的研究表明，死者甲状腺组织中的放射性碘含量与他们离英国坎布里亚郡塞拉菲尔德核设施的距离成反比。目的:本研究旨在确定在过去十年中，坎布里亚郡各地区甲状腺癌的发病率。方法:一项经伦理批准的回顾性队列研究，将坎布里亚郡各地区每10万人中年龄标准化甲状腺癌发病率与英国平均水平进行比较。结论:本研究显示，西坎布里亚郡甲状腺癌的明显低发病率持续存在，尽管由于诊断的甲状腺癌数量有限，没有观察到统计学上的显著差异。进一步的研究——可能涉及居住在放射性碘排放源附近的人口——表明要调查是否有任何机制构成这一明显趋势的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of thyroid disorders & therapy

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