Exploring the anti-cancer effect of taraxasterol using network pharmacology, molecular docking and in vitro experimental validation

Abstract

Taraxasterol (TS) is a naturally occurring pentacyclic triterpenoid extracted from the traditional Chinese herb Taraxacum mongolicum . Previous studies have highlighted its significant roles in exhibiting anti-inflammatory, anti-oxidant, and liver protective effects. In the present study, the anti-cancer potential of TS against cervical cancer was investigated, employing network pharmacology techniques, molecular docking, and in vitro experimental validation. TS exhibits its anticancer properties by modulating multiple targets, pathways, and biological processes. In vitro experiments demonstrated the potent inhibitory effects of TS on cancer cell growth and migration, while no significant impact on apoptosis was observed. The primary objective was to elucidate the anti-cancer potential of TS, which is a crucial lead compound in the treatment of cervical cancer. The findings may serve as a basis for the development of novel anticancer therapeutics and medicine-based interventions for cervical cancer.