The Effect of Estrogen and Progesterone Receptor Status on the Prognosis of Endometrioid Type Endometrial Cancer: Retrospective Study

Abstract

ABS TRACT Objective: Endometrioid-type endometrial cancer (EC) is the most common histological type of EC, and generally has good survival if diagnosed during the early stages. While tumour grade, stage and lymph node invasion are known to affect survival in these patients, the prognostic significance of steroid receptor status remains unclear. The present study aimed to determine the effect of estrogen and progesterone receptor (ER and PR, respectively) status and its relationship with other prognostic factors in endometrioid-type EC. Material and Methods: Data from 152 patients who underwent surgery at the same centre between 2009 and 2019 were retrospectively evaluated. Histological characteristics of tumours were determined using the original pathology reports, and stage, grade and lymph node involvement of tumours were compared with ER and PR status. The relationship between ER and PR status and preoperative serum cancer antigen 125 and albumin levels were also investigated. Results: When the results of our study were examined, it was revealed that 114 patients had Grade I tumor and 118 had International Federation of Gynecology and Obstetrics Stage I tumor and 34 patients had ER and PR negativity. In our study, a dependence was found between both ER and PR status and pelvic lymph node involvement. It was found that the possibility of pelvic lymph node involvement increases in both hormone receptor negativity. Conclusion: This study reports that the patients with pelvic lymph node involvement, which is a prognostic factor in EC, may experience more frequent ER and PR negativity. However, its effects on survival remain unclear.