Longitudinal, Whole-population Data Examining Pathways of Risk from Conception to Disease: The Western Australian Schizophrenia High-risk e-Cohort

Open health data Pub Date : 2014-09-22 DOI:10.5334/OHD.AJ
V. Morgan, G. Valuri, M. Croft, Sonal Shah, P. D. Prinzio, Jennifer A. Griffith, T. Mcneil, A. Jablensky
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Abstract

This database has been constructed to support a program of work designed to untangle genetic and environmental contributions to the risk for schizophrenia and other adverse outcomes in the offspring of mothers with schizophrenia and other severe mental illness. To do this, it utilises Western Australian whole-population health and social services databases. Records on the Western Australian psychiatric case register have been linked to Midwives’ Notification of Birth records and to Registrations of Births (for paternal links) as well as to other data sets. Maternal links identify women with psychosis who gave birth in Western Australia between 1980 and 2001. Comparison mothers are those with no record of psychiatric illness who gave birth in Western Australia over the same period. The study database comprises 246,873 mothers and 467,945 children: 889 mothers with schizophrenia (1,672 children); 1,644 mothers with bipolar disorder (3,358 children); 4,200 mothers with unipolar major depression (8,864 children); 775 mothers with other psychoses (1,592 children); and 239,365 comparison mothers (452,459 children). Full psychiatric histories for mothers, fathers and children have been extracted. At the time of the most recent update to the psychiatric data on children, 33,363 children had a history of psychiatric illness; 5,500 of these had had at least one contact with mental health services at which a diagnosis of a psychotic disorder had been recorded. Data have also been collected on obstetric complications and a range of infant and childhood morbidities including birth defects, intellectual disability, educational achievement, childhood abuse, criminal offending. The program aims are to: (i) determine the frequency and distribution of obstetric complications in women with schizophrenia compared to a non-psychiatric comparison group of mothers; (ii) explore the spectrum of outcomes for the children born to women with schizophrenia compared to comparison children, and to assess the specificity of these findings to maternal schizophrenia compared to maternal bipolar disorder, unipolar major depression and other psychotic illness; and (iii) examine the relationship between familial psychiatric status, obstetric complications and mental health outcomes for children. The data sit in an Ingres relational database. A full description of the database and its elements has been published [1]. Numbers in this article differ from previously published numbers as a result of new linkages and updates to the database.
纵向,全人群数据检查从受孕到疾病的风险途径:西澳大利亚精神分裂症高风险e队列
该数据库的建立是为了支持一项工作计划,该计划旨在解开遗传和环境因素对精神分裂症风险的影响,以及对患有精神分裂症和其他严重精神疾病的母亲的后代的其他不良后果的影响。为此,它利用了西澳大利亚州全体人口健康和社会服务数据库。西澳大利亚精神病病例登记册上的记录已与助产士出生通知记录和出生登记(父系联系)以及其他数据集联系起来。在1980年至2001年期间在西澳大利亚州分娩的女性患有精神疾病。对照母亲是指同期在西澳大利亚州分娩的没有精神疾病记录的母亲。该研究数据库包括246,873名母亲和467,945名儿童:889名患有精神分裂症的母亲(1,672名儿童);1644名患有双相情感障碍的母亲(3358名儿童);4200名患有单极重度抑郁症的母亲(8864名儿童);775名患有其他精神病的母亲(1592名儿童);239365名母亲(452459名孩子)作为对照。母亲、父亲和孩子的完整精神病史已经被提取出来。在最近一次更新儿童精神病学数据时,有33,363名儿童有精神病史;其中5,500人至少与精神卫生服务机构有过一次接触,并被诊断患有精神病。还收集了关于产科并发症和一系列婴儿和儿童发病率的数据,包括出生缺陷、智力残疾、教育成就、儿童虐待、犯罪。该方案的目的是:(i)确定精神分裂症妇女与非精神病对照组母亲相比产科并发症的频率和分布;(ii)探索精神分裂症妇女所生儿童与对照儿童的结局谱,并评估这些发现与母亲精神分裂症与母亲双相情感障碍、单极重性抑郁症和其他精神疾病相比的特异性;(三)研究家庭精神状况、产科并发症和儿童心理健康结果之间的关系。数据位于Ingres关系数据库中。数据库及其元素的完整描述已在[1]上发布。由于对数据库进行了新的连接和更新,本文中的数字与以前公布的数字有所不同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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