Naeema Al Shibli, Azza Al Shidhani, Irfan Ullah, Hussain AlSaffar, Faris Al Kalbani, Koukab Al Farsi, Jalila Alshekaili, Nafila Al Riyami
{"title":"Interference with Immunoassays of a Neonate on High Biotin: Case Report and Literature Review.","authors":"Naeema Al Shibli, Azza Al Shidhani, Irfan Ullah, Hussain AlSaffar, Faris Al Kalbani, Koukab Al Farsi, Jalila Alshekaili, Nafila Al Riyami","doi":"10.5001/omj.2024.30","DOIUrl":null,"url":null,"abstract":"<p><p>Biotin is sometimes administered in mega doses to children to treat certain inborn errors of metabolism. We report the case of a one-week-old newborn who was started on a 'mitochondrial cocktail' that contained a high dose of biotin. On day seven of life, his thyroid function test showed a biochemical picture of primary hyperthyroidism, which was not clinically evident. The suspicion of immunoassay interference with thyroid function test was confirmed when another lab, using a different immunoassay, gave normal results. If the biochemical profile does not match the clinical picture, it is reasonable to doubt the test result and think of assay interference.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"4 Suppl s4 1","pages":"e679"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873207/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oman Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5001/omj.2024.30","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Biotin is sometimes administered in mega doses to children to treat certain inborn errors of metabolism. We report the case of a one-week-old newborn who was started on a 'mitochondrial cocktail' that contained a high dose of biotin. On day seven of life, his thyroid function test showed a biochemical picture of primary hyperthyroidism, which was not clinically evident. The suspicion of immunoassay interference with thyroid function test was confirmed when another lab, using a different immunoassay, gave normal results. If the biochemical profile does not match the clinical picture, it is reasonable to doubt the test result and think of assay interference.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
