Genome editing in therapy: immunological context

IF 0.2 Q4 ALLERGY

Alergologia Polska - Polish Journal of Allergology Pub Date : 2021-01-01 DOI:10.5114/pja.2021.111801

P. Rieske

引用次数: 0

Abstract

obie-cujące lub mukowiscydozie. Edycja genomu autogennych T z chimerycznym receptorem antygenowym ( chimeric antigen receptor T-cells – CAR-T). Edycja genomu w połączeniu z technologią iPSc powinna umożliwić otrzymanie tzw. uniwersalnych komórek do transplantacji, w tym uniwersalnych CAR-T. Edycja genomu jest więc szczególnie istotna kontekście immunologicznym. abStract Genome editing of induced pluripotent stem cells (iPSc) or hematopoietic tolerancji immunologicznej, ale ta zmienna jest istotna [4, 5]. Chorób warunkowanych występowaniem mutacji typu nonsens jest wiele, symptoms depend on blood cell dysfunction than, for example, in muscular dystrophy or cystic fibrosis. Genome editing is also used to refine autogenous T cells with chimeric antigen receptor T-cells (CAR-T). Finally, genome editing in combination with iPSc technology should enable the production of the so-called universal for transplantation, including universal CAR-T. Genome editing is therefore particularly important in an immunological context.

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治疗中的基因组编辑:免疫学背景

双极性或囊性纤维化。用嵌合抗原受体T细胞（CAR-T）编辑自体T基因组。基因组编辑与iPSc技术相结合，应该可以获得所谓的。通用移植细胞，包括通用CAR-T。因此，基因组编辑是一个特别重要的免疫背景。abStract诱导多能干细胞（iPSc）或造血免疫耐受的基因组编辑，但该变量是相关的[4，5]。以无义突变发生为条件的疾病有很多，症状取决于血细胞功能障碍，而不是肌肉营养不良或囊性纤维化。基因组编辑也被用于用嵌合抗原受体T细胞（CAR-T）纯化自体T细胞。最后，基因组编辑与iPSc技术相结合，应该能够产生所谓的通用移植，包括通用CAR-T。因此，基因组编辑在免疫学方面尤为重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alergologia Polska - Polish Journal of Allergology ALLERGY-

自引率

50.00%

发文量

期刊介绍： Alergologia Polska - Polish Journal of Allergology is aimed mainly at allergologists, but also medical doctors working in related fields, such as otolaryngology, pulmonology, and dermatology. The main goal of the journal is to ensure rapid publication of important research papers and interesting case studies from the following areas: allergology, diagnostics, therapy of allergic diseases, in particular in the area of immunotherapy, rhinitis, asthma. The Editorial Board accepts for publication original papers, case studies and letters to the Editor. We also publish review articles (both commissioned and those agreed upon with the Editor-in-Chief), articles dealing with standards of medical practice, as well as special issues. The journal is published quarterly. We guarantee short review times (up to two weeks) and immediate publication on-line upon Editor acceptance.