Biological Relationships between miRNAs used for Colorectal Cancer Screening

Journal of molecular biomarkers & diagnosis Pub Date : 2018-01-01 DOI:10.4172/2155-9929.1000398

M. Herreros-Villanueva, R. Pérez-Palacios, Sergio Castillo, C. Segú, Teresa Sardon, J. Mas, A. C. Martín, R. Arroyo

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引用次数: 4

Abstract

MicroRNAs have been proposed to function as biomarkers in several disorders including cancer. Particularly, those present in plasma samples have been validated for colon cancer screening purposes. However, mechanisms underlying miRNA regulating CRC development have not been fully investigated yet. The aim of this study was to perform a biological contextualization of a particular 6 miRNAs signature (Hsa-miR-15b-5p, Hsa-miR-18a-5p, Hsa-miR-29a-3p, Hsa-miR335-5p, Hsa-miR-19a-3p and Hsa-miR-19b-3p) already described as CRC screening tool in terms of its downstream targets and associated pathways, to understand how this set of miRNAs could be regulating colon cancer development. Our results demonstrated that Hsa-miR-15b-5p, Hsa-miR-18a-5p and HsamiR-29a-3p are the best contributors to the diagnostic value of the signature by regulating epithelial to mesenchymal transformation though a gained balance of inhibiting tumoral suppressors genes such as ETS2, TP53, TLE3, ACVR2A.

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用于结直肠癌筛查的mirna之间的生物学关系

microrna已被认为是包括癌症在内的几种疾病的生物标志物。特别是，血浆样本中存在的这些物质已被证实可用于结肠癌筛查。然而，miRNA调控结直肠癌发展的机制尚未得到充分研究。本研究的目的是对特定的6种mirna特征(Hsa-miR-15b-5p, Hsa-miR-18a-5p, Hsa-miR-29a-3p, Hsa-miR335-5p, Hsa-miR-19a-3p和Hsa-miR-19b-3p)进行生物学背景分析，这些特征已经被描述为CRC筛查工具，就其下游靶点和相关途径而言，以了解这组mirna如何调节结肠癌的发展。我们的研究结果表明，Hsa-miR-15b-5p、Hsa-miR-18a-5p和HsamiR-29a-3p是通过平衡抑制肿瘤抑制基因(如ETS2、TP53、TLE3、ACVR2A)来调节上皮细胞向间质细胞转化的标志的诊断价值的最佳贡献者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of molecular biomarkers & diagnosis

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