Serum zinc changes in term neonates with hyperbilirubinemia after phototherapy

Current Pediatric Research Pub Date : 2021-01-01 DOI:10.4172/456

Aida A Manthar

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Abstract

Background: Neonatal jaundice occurs due to the elevated levels of unconjugated bilirubin and may induce neurological sequelae, such as encephalopathy. Phototherapy remains the main primary management in neonatal jaundice; one of its effects is elevated in zinc level. Objectives: Assess serum zinc level in full term neonates who had hyperbilirubinemia and treated by phototherapy before and after phototherapy and study it`s relation to selected neonatal, maternal and labour factors. Methods: A prospective study has been carried out in Basrah Maternity and Children Hospital, 2nd neonatal care unit to assess serum zinc on 60 term neonates appropriate for gestational age with unconjugated hyperbilirubinemia treated by phototherapy. Neonatal, maternal data were collected, serum zinc was assessed before and after phototherapy, (normal range: 50-150 μg/dL), elevated in serum zinc was studied in relation to selected variables. Results: It was found that total serum bilirubin was lower after phototherapy and serum zinc was elevated. The result is statistically significant. Elevated serum zinc was found in 33.3% of cases. It was more in in extensive phototherapy than double or single. P value < 0.05. Also, more with prolonged period of phototherapy but the result was statistically not significant. It was not related to other neonatal or maternal characters. Conclusion: Serum zinc is elevated after phototherapy in neonates with hyperbilirubinemia, increase level is more with use of extensive phototherapy and increase level of total serum bilirubin.

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高胆红素血症足月新生儿光疗后血清锌的变化

背景:新生儿黄疸的发生是由于未结合胆红素水平升高，并可能引起神经系统后遗症，如脑病。光疗仍然是新生儿黄疸的主要治疗方法;它的作用之一是提高锌的含量。目的:评价光疗治疗足月高胆红素血症新生儿光疗前后血清锌水平，并探讨其与选定的新生儿、产妇和分娩因素的关系。方法:在巴士拉妇幼医院第二新生儿护理病房进行前瞻性研究，评估60例胎龄适宜的非结合性高胆红素血症足月新生儿光疗后的血清锌含量。收集新生儿、产妇资料，测定光疗前后血清锌含量(正常范围:50 ~ 150 μg/dL)，研究血清锌升高与选定变量的关系。结果:光疗后血清总胆红素降低，血清锌升高。结果具有统计学意义。33.3%的患者血清锌升高。它在广泛的光疗中比双重或单一的更有效。P值< 0.05。光疗时间越长，效果越明显，但差异无统计学意义。它与其他新生儿或母体特征无关。结论:高胆红素血症新生儿光疗后血清锌升高，且广泛光疗后升高幅度更大，血清总胆红素升高幅度更大。

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来源期刊

Current Pediatric Research Medicine-Pediatrics, Perinatology and Child Health

自引率

0.00%

发文量

145

期刊介绍： Current Pediatric Research is an interdisciplinary Research Journal for publication of original research work in all major disciplines of Pediatric Research. The objective of the journal is to provide a scientific communication medium to discuss the utmost advancements in the domain of Pediatric Research. This journal aims to assemble and reserve precise, specific, detailed data on this immensely diversified subject. Current Pediatric Research is scientific open access journal that specifies the development activities conducted in the field of pediatric research. This journal encompasses the study related to different diversified aspects in pediatric research such as Pediatric Nursing, pediatric emergency care, pediatric nephrology, pediatric pulmonology, pediatric psychology, pediatric dental care, pediatric diabetes, pediatric stroke, pediatric healthcare, pediatric congenital heart disease, pediatric trauma and many more relevant fields.