HEMATOLOGICAL, METABOLIC AND RHEOLOGICAL CHARACTERISTICS OF ERYTHROCYTES IN RECOMBINANT HUMAN ERYTHROPOIETIN-ADMINISTERED RAT II. Rheological Properties

Nihon Yuketsu Gakkai zasshi = Journal of the Japan Society of Blood Transfusion Pub Date : 2010-01-01 DOI:10.3925/jjtc1958.35.633

N. Maeda

{"title":"HEMATOLOGICAL, METABOLIC AND RHEOLOGICAL CHARACTERISTICS OF ERYTHROCYTES IN RECOMBINANT HUMAN ERYTHROPOIETIN-ADMINISTERED RAT II. Rheological Properties","authors":"N. Maeda","doi":"10.3925/jjtc1958.35.633","DOIUrl":null,"url":null,"abstract":"HEMATOLOGICAL, METABOLIC AND RHEOLOGICAL CHARACTERISTICS OF ERYTHROCYTES IN RECOMBINANT HUMAN ERYTHROPOIETIN-ADMINISTERED RAT II. Rheological Properties Nobuji Maeda Department of Physiology, School of Medicine, Ehime University Rheological properties of erythrocytes induced by intravenous administration of recombinant human erythropoietin (rhEPO; 180 or 1800 IU/kg daily) to 6 weeks-old rats for 1 or 2 weeks were examined. (1) Increase of blood viscosity was entirely dependent upon the hematocrit. (2) No change of erythrocyte deformability was detected with a high shear rheoscope, in spite of the appearance of large and light (presumably, young) erythrocytes. (3) Velocity of rouleau formation in autologous plasma decreased, probably due to high density of negative charge on the surface of young erythrocytes. In addition, the composition of plasma proteins was not affected by rhEPO-administration. (4) Upon the long-term administration, these rheological findings were not essentially altered.","PeriodicalId":86521,"journal":{"name":"Nihon Yuketsu Gakkai zasshi = Journal of the Japan Society of Blood Transfusion","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nihon Yuketsu Gakkai zasshi = Journal of the Japan Society of Blood Transfusion","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3925/jjtc1958.35.633","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

HEMATOLOGICAL, METABOLIC AND RHEOLOGICAL CHARACTERISTICS OF ERYTHROCYTES IN RECOMBINANT HUMAN ERYTHROPOIETIN-ADMINISTERED RAT II. Rheological Properties Nobuji Maeda Department of Physiology, School of Medicine, Ehime University Rheological properties of erythrocytes induced by intravenous administration of recombinant human erythropoietin (rhEPO; 180 or 1800 IU/kg daily) to 6 weeks-old rats for 1 or 2 weeks were examined. (1) Increase of blood viscosity was entirely dependent upon the hematocrit. (2) No change of erythrocyte deformability was detected with a high shear rheoscope, in spite of the appearance of large and light (presumably, young) erythrocytes. (3) Velocity of rouleau formation in autologous plasma decreased, probably due to high density of negative charge on the surface of young erythrocytes. In addition, the composition of plasma proteins was not affected by rhEPO-administration. (4) Upon the long-term administration, these rheological findings were not essentially altered.

查看原文本刊更多论文

重组人促红细胞生成素大鼠红细胞的血液学、代谢和流变学特性研究ii。流变特性

重组人促红细胞生成素大鼠红细胞的血液学、代谢和流变学特性研究ii。静脉给药重组人促红细胞生成素(rhEPO)诱导红细胞的流变学特性180或1800 IU/kg每日)至6周龄大鼠，持续1或2周。(1)血液黏度的增加完全取决于红细胞压积。(2)高剪切流变镜未检测到红细胞变形能力的变化，尽管红细胞看起来又大又轻(可能是年轻的)。(3)自体血浆中rouleau形成速度减慢，可能是由于年轻红细胞表面的高密度负电荷所致。此外，血浆蛋白的组成不受rhepo给药的影响。(4)长期服用后，这些流变学结果并未发生本质改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nihon Yuketsu Gakkai zasshi = Journal of the Japan Society of Blood Transfusion

自引率

0.00%

发文量