THE DISTRIBUTION OF HLA-A, B, C, Bf, C4 AND TWO LOCUS ASSOCIATION OF HEALTHY APHERESIS DONNOR IN YAMAGUCHI PREFECTURE, WESTERN AREA OF JAPAN

Abstract

THE DISTRIBUTION OF HLA-A, B, C, Bf, C4 AND TWO LOCUS ASSOCIATION OF HEALTHY APHERESIS DONNOR IN YAMAGUCHI PREFECTURE, WESTERN AREA OF JAPAN Hidenori Tanaka, Keiichi Itoh and Kazuya Hirakawa Yamaguchi Red Cross Blood Center HLA-A, B, C, Bf, C4 gene and haplotype frequency were studied in 311 healthy apheresis donnors living in Yamaguchi prefecture of western area of Japan and the result was compared with the previous study of Japanes. In HLA-A, B, C locus, the gene frequency of Aw33, B44, Bw54, Cwl were decresed, and the gene frequency of B7, Cw7 were increased. In Bf locus, the gene frequency of BfF was significantly decreased, and with regards to the distribution of Bf gene frequency, there is a similarity to the Southern Chinese. Distribution of the gene frequency of C4 locus was not so different from average of Japanese, but C4A*4 and C4B*2 just increased. The haplotype frequency of Aw33-CBL-B44-C4A3-C4B1-BfF was significantly decreased, and the haplotype frequency of A24-Cw7-B7-C4A3-C4B1-BfS was increased.