Neural stem cell derived tumourigenesis

Francesca Froldi, M. Szuperak, Louise Y. Cheng
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引用次数: 1

Abstract

Abstract In the developing Drosophila CNS, two pools of neural stem cells, the symmetrically dividing progenitors in the neuroepithelium (NE) and the asymmetrically dividing neuroblasts (NBs) generate the majority of the neurons that make up the adult central nervous system (CNS). The generation of a correct sized brain depends on maintaining the fine balance between neural stem cell self-renewal and differentiation, which are regulated by cell-intrinsic and cell-extrinsic cues. In this review, we will discuss our current understanding of how self-renewal and differentiation are regulated in the two neural stem cell pools, and the consequences of the deregulation of these processes.
神经干细胞衍生的肿瘤发生
在发育中的果蝇中枢神经系统(CNS)中,神经上皮(NE)中对称分裂的祖细胞和不对称分裂的神经母细胞(NBs)这两个神经干细胞池产生了构成成年中枢神经系统(CNS)的大部分神经元。正确大小的大脑的产生取决于神经干细胞自我更新和分化之间的良好平衡,这是由细胞内在和细胞外在信号调节的。在这篇综述中,我们将讨论我们目前对两种神经干细胞池中自我更新和分化是如何调节的理解,以及放松这些过程的后果。
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来源期刊
AIMS Genetics
AIMS Genetics GENETICS & HEREDITY-
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