Remarkable Indications-How the Glycomics is Coded in Cells and Tissues

Jozef Nahalka
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Abstract

It is presupposed that N-glycosylation encodes crucial information about the protein’s structure-function, its age and its localization. Although N-glycosylation is often described as posttranslational modification, recent studies show that it occurs cotranslationally. During translation, ribosome is attached to a proteintranslocation channel in the endoplasmic reticulum membrane and a nascent polypeptide is threaded through the channel, and oligosaccharyltransferase, adjacent to the channel, catalyses the attachments of oligosaccharide to the polypeptide chain before the protein acquire secondary or tertiary structure [1]. This commentary highlights connection between mentioned process of the glycoprotein folding and glycan–protein interactions on cell surfaces. Seems to be, both processes use special amino acid triplets (glycocodons) for programming of glycomics events, and this coding has relationship with the genetic code.
显著的适应症-糖组学如何在细胞和组织中编码
假设n -糖基化编码有关蛋白质结构-功能,年龄和定位的关键信息。虽然n -糖基化通常被描述为翻译后修饰,但最近的研究表明它发生在共翻译中。在翻译过程中,核糖体附着在内质网膜上的蛋白质易位通道上,新生多肽穿过通道,通道附近的低聚糖转移酶在蛋白质获得二级或三级结构[1]之前催化低聚糖附着在多肽链上。这篇评论强调了上述糖蛋白折叠过程与细胞表面聚糖-蛋白相互作用之间的联系。似乎这两个过程都使用特殊的氨基酸三联体(糖茧子)来编程糖组学事件,并且这种编码与遗传密码有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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