{"title":"Remarkable Indications-How the Glycomics is Coded in Cells and Tissues","authors":"Jozef Nahalka","doi":"10.4172/2153-0637.1000E107","DOIUrl":null,"url":null,"abstract":"It is presupposed that N-glycosylation encodes crucial information about the protein’s structure-function, its age and its localization. Although N-glycosylation is often described as posttranslational modification, recent studies show that it occurs cotranslationally. During translation, ribosome is attached to a proteintranslocation channel in the endoplasmic reticulum membrane and a nascent polypeptide is threaded through the channel, and oligosaccharyltransferase, adjacent to the channel, catalyses the attachments of oligosaccharide to the polypeptide chain before the protein acquire secondary or tertiary structure [1]. This commentary highlights connection between mentioned process of the glycoprotein folding and glycan–protein interactions on cell surfaces. Seems to be, both processes use special amino acid triplets (glycocodons) for programming of glycomics events, and this coding has relationship with the genetic code.","PeriodicalId":89585,"journal":{"name":"Journal of glycomics & lipidomics","volume":"02 1","pages":"1-2"},"PeriodicalIF":0.0000,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of glycomics & lipidomics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2153-0637.1000E107","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
It is presupposed that N-glycosylation encodes crucial information about the protein’s structure-function, its age and its localization. Although N-glycosylation is often described as posttranslational modification, recent studies show that it occurs cotranslationally. During translation, ribosome is attached to a proteintranslocation channel in the endoplasmic reticulum membrane and a nascent polypeptide is threaded through the channel, and oligosaccharyltransferase, adjacent to the channel, catalyses the attachments of oligosaccharide to the polypeptide chain before the protein acquire secondary or tertiary structure [1]. This commentary highlights connection between mentioned process of the glycoprotein folding and glycan–protein interactions on cell surfaces. Seems to be, both processes use special amino acid triplets (glycocodons) for programming of glycomics events, and this coding has relationship with the genetic code.