Chemical composition and toxicity of extracts of Fouquieria splendens against Artemia salina

IF 1.9 Q2 AGRICULTURE, MULTIDISCIPLINARY

AIMS Agriculture and Food Pub Date : 2022-01-01 DOI:10.3934/agrfood.2022023

L. O. Nevarez-Prado, Nubia I. AMAYA-OLIVAS, Alejandro Sustaita-Rodríguez, J. Rodríguez-Zapién, Erick Zúñiga-Rodríguez, María Cordova-Lozoya, A. García-Triana, F. Sandoval-Salas, L. Hernández-Ochoa

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引用次数: 0

Abstract

Ocotillo (Fouquieria splendens) has been used in Mexican traditional medicine for the treatment of blood circulation problems, swelling, and prostatic hyperplasia, among others. The objective of this study was to use different extraction methods (soxhlet, hydrodistillation and ultrasound) and solvents with different polarities (hexane, methyl chloride, ethyl acetate, acetone and methanol) to determine volatile compounds contained in ocotillo stems. Solvents used were water in hydrodistillation; hexane, methyl chloride, ethyl acetate, acetone, and methanol in soxhlet; and a solvent mixture of water acidified with methanol, acetone, and 1% acetic acid at a 50:35:15 ratio in the ultrasound method. The major components identified were bis (2-Ethylhexyl) phthalate, bis (2-Ethylhexyl) ester, butyl acetate, palmitic acid, and myristic acid. A toxicity assay on Artemia salina was conducted and the median lethal concentration was quantified. The bioassay showed that extracts isolated by non-polar solvents are extremely toxic because they were lethal at concentrations lower than 100 ppm, while polar extracts were innocuous. However, in polar extracts were found compounds that suggest their use in traditional medicine, the most relevant being 2-butoxyethanol, pentadecanol, and undecanal.

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锦绣草提取物对盐渍蒿的化学成分及毒性研究

Ocotillo (Fouquieria splendens)在墨西哥传统医学中用于治疗血液循环问题、肿胀和前列腺增生等。本研究的目的是采用不同的提取方法(索氏法、加氢蒸馏法和超声波法)和不同极性的溶剂(己烷、氯甲烷、乙酸乙酯、丙酮和甲醇)来测定牛头草茎中的挥发性化合物。在加氢蒸馏中使用的溶剂是水;索氏正己烷、氯甲烷、乙酸乙酯、丙酮和甲醇;以及用甲醇、丙酮和1%醋酸按50:35:15的比例酸化的水的溶剂混合物。主要成分为邻苯二甲酸双(2-乙基己基)酯、双(2-乙基己基)酯、乙酸丁酯、棕榈酸和肉豆酱酸。对盐渍蒿进行毒性试验，定量测定中位致死浓度。生物测定表明，非极性溶剂萃取物在浓度低于100ppm时具有致命毒性，而极性溶剂萃取物则无害。然而，在极性提取物中发现的化合物表明它们在传统医学中的用途，最相关的是2-丁氧基乙醇、戊烷醇和十一烷醇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIMS Agriculture and Food AGRICULTURE, MULTIDISCIPLINARY-

CiteScore

3.70

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： AIMS Agriculture and Food covers a broad array of topics pertaining to agriculture and food, including, but not limited to:  Agricultural and food production and utilization  Food science and technology  Agricultural and food engineering  Food chemistry and biochemistry  Food materials  Physico-chemical, structural and functional properties of agricultural and food products  Agriculture and the environment  Biorefineries in agricultural and food systems  Food security and novel alternative food sources  Traceability and regional origin of agricultural and food products  Authentication of food and agricultural products  Food safety and food microbiology  Waste reduction in agriculture and food production and processing  Animal science, aquaculture, husbandry and veterinary medicine  Resources utilization and sustainability in food and agricultural production and processing  Horticulture and plant science  Agricultural economics.