Analysis on clinical characteristics and prognosis in 248 cases of COVID-19 in Chongqing city.

Abstract

Objective To explore and analyze the clinical characteristics and prognosis of 248 patients with novel coronavirus pneumonia (COVID-19) in Chongqing, so as to provide reference for clinical diagnosis and treatment of COVID-19. Methods The clinical data of 248 patients with COV ID-19 admitted to the hospital from January 21 to March 11, 2020 were retrospectively analyzed, including 195 patients in the non-severe group (mild type/normal type) and the severe group (severe type/critical type). Type) 53 cases. Comparing the general conditions, clinical manifestations, laboratory test results and prognosis of the two groups of patients, the average age of 248 patients was (47.69±15.59) years old. Adults accounted for 97.6% (242/248), men were slightly more than women (54.0% (134/248), 46.0% (114/248), respectively), hospitalization time was 14.00 (12.00, 22,000 days. The fatality rate was 16% ( 4/248), the fatality rate of patients in the severe group was 7.5% (4/53). After the cured patients were discharged from the hospital, 4 patients in the non-critical group were followed up for reimpedance, and there was no evidence of infecting others. The age of the severe group patients, as well as diabetes and chronic obstruction The proportions of pulmonary disease, coronary heart disease, malignant tumors, cough, sputum, shortness of breath, dyspnea, and fatigue are all significantly higher than those of the non-severe group. The counts of lymphocytes, monocytes, lymphocytes, total T lymphocytes, Helper/inducible T lymphocytes, inhibitory/cytotoxic T lymphocytes, B lymphocytes, and natural killer cells are significantly lower than the non-severe group, neutrophils, urea nitrogen, direct bilirubin, aspartate aminotransferase, prothrombin time, Partially activated prothrombin time, D-dimer. C-reactive protein, procalcitonin, and interleukin-6 were significantly higher than those in the non-critical group, and the differences were statistically significant (P<0.05). Conclusions Elderly Patients with diabetes mellitus, chronic obstructive pulmonary disease, coronary heart disease, malignant tumors and other diseases are more likely to progress to severe cases. Clinical medical advancement combines patient symptoms and related laboratory test results to identify critically ill patients early and admit them to the intensive care unit for enhanced monitoring and treatment. Reduce the fatality rate of COVID 19 patients. (English) [ABSTRACT FROM AUTHOR] 目的探讨并分析重庆市 248 例新型冠状病毒肺炎(COVID-19)患者的临床特征和预后,为临 床诊疗 COVID-19 提供参考依据。方法回顾性分析2020年1月21日至3月11日该院收治的248例COV ID-19 患者的临床资料,其中非重症组(轻微型/普通型)195例,重症组(重型/危重型)53例。比较2组患者一 般情况､临床表现、实验室检验结果及预后等,结果 248例患者平均年龄(47.69±15.59)岁。成人占97.6% (242/248),男性稍多于女性[分别为54.0%(134/248)、46.0%(114/248)],住院时间 14.00 (12.00,22,000d. 病死率为16%(4/248),重症组患者病死率为7.5%(4/53),治愈患者出院后随访4例非重症组患者复阻,无传 染他人的证据,重症组患者年龄,以及合并糖尿病、慢性阻塞性肺疾病､冠心病、恶性肿瘤比例,出现咳嗽、咳 痰､气促、呼吸困难、乏力比例均明显高于非重症组,入院时淋巴细胞、单核细胞 淋巴细胞计数､总T淋巴细胞、 辅助/诱导T淋巴细胞､抑制/细胞毒T淋巴细胞、B淋巴细胞、自然杀伤细胞均明显低于非重症组,中性粒细 胞､尿素氮､直接胆红素､谷草转氨酶､凝血酶原时间,部分活化凝血酶原时间､D-二聚体.C反应蛋白､降钙素 原、白细胞介素-6均明显高于非重症组,差异均有统计学意义(P<0.05)。结论老年患者合并糖尿病,慢性阻 塞性肺疾病、冠心病、恶性肿瘤等疾病更易进展为重症病例,临床医升 结合患者症状及相关实验室检查结果 早期识别重症患者并收住重症监护病房加强监护治疗,从而降低COVID 19患者病死率. (Chinese) [ABSTRACT FROM AUTHOR] Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)