Research progress in mechanisms of drug resistance in cancer stem cells

Q4 Pharmacology, Toxicology and Pharmaceutics

中国药理学通报 Pub Date : 2012-12-01 DOI:10.3969/J.ISSN.1001-1978.2012.12.003

Xiaohui Zhao, L. Fu

引用次数: 0

Abstract

Cancer is a stem cell disease.A major challenge in treating cancer is the resistance to conventional therapies,which is demonstrated to be related to the cancer stem cells(CSCs) that are responsible for the sustained cancer growth,survival and invasion.Identifying these stem cells in different cancers and defining the microenvironment and the biologic processes necessary for their existence is paramount in developing new clinical approaches with the goal of preventing disease recurrence.The alteration of local microenvironment(niche) around the CSCs,the aberrant activation of development associated signaling pathways,the excessive enhancement of DNA damage repair and the efflux of anticancer drugs mediated by ABC transporters are the main causes of clinical resistance to therapy.This review will briefly outline the cellular and molecular mechanisms underlying cancer progression,focusing on the resistance to therapy.

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肿瘤干细胞耐药机制的研究进展

癌症是一种干细胞疾病。癌症治疗的一个主要挑战是对常规疗法的耐药性，这被证明与癌症干细胞(CSCs)有关，CSCs负责癌症的持续生长、存活和侵袭。识别不同癌症中的这些干细胞并确定其存在所需的微环境和生物学过程对于开发新的临床方法以预防疾病复发至关重要。CSCs周围局部微环境(生态位)的改变、发育相关信号通路的异常激活、DNA损伤修复的过度增强以及ABC转运体介导的抗癌药物外排是临床耐药的主要原因。这篇综述将简要概述癌症进展的细胞和分子机制，重点是对治疗的抵抗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国药理学通报 Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

0.80

自引率

0.00%

发文量

11201

期刊介绍： Chinese Pharmacological Bulletin (CPB) is an academic monthly magazine sponsored by the Chinese Association for Science and Technology, the Chinese Pharmacological Society, and Anhui Medical University. Publicly issued domestically and internationally, CN:34:1086/R,ISSN:1001-1978。 The inclusion status of Chinese Pharmaceutical Bulletin (CPB): 1. This journal has been identified as a core medical journal by the China Science Citation Database (CSCD) of the Document Information Center of the Chinese Academy of Sciences (since 1993, there are 909 journals in the core library); 2. Selected as a pharmaceutical core journal by the editor in chief of Peking University Library's "Overview of Chinese Core Journals" (Peking University Core), 1st to 8th editions (1243 scientific and technological journals, including 232 medical and health journals); 3. Designated by the Institute of Science and Technology Information of the Ministry of Science and Technology of China as a source journal for Chinese scientific and technological paper statistics (China Science and Technology Core Journal); 4. Other: Domestic: Chinese Academic Journal Abstracts, Chinese Basic Medical Abstracts, Chinese Pharmaceutical Abstracts, Chinese Biological Abstracts, Chinese Academic Journals (CD version), Wanfang Database, VIP Database, etc; International: Chemical Abstract (USA), Corrective Bulletin on Science and Technology, CBST (Japan), Biological Abstract (USA), Biochemical Abstract (USA), EMBASE/Excerpta Medica (Netherlands), Index Copernicus (Poland), Kunst and Wissen (Germany), WPRIM (World Health Organization Western Pacific Regional Medical Index), Scopus (Netherlands, 2019 CiteScore 0.9), A&I (Netherlands), Centre for Agriculture and Biosciences international (CAB international, UK), Biosis Previews (USA), etc.