Effects of electroacupuncture on unaffected limbs at very early stage of cerebral local focus ischemia in rats

Q4 Medicine

中国康复医学杂志 Pub Date : 2012-01-01 DOI:10.3969/J.ISSN.1001-1242.2012.09.005

Liping Huang, H. Xiang, N. Xiao, Shi Zhou, L. Caso, Wenlong Wang, Jianqi Zhang, Q. Tian

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引用次数: 0

Abstract

Objective:To determine the effects of electroa cupuncture(EA) treatment on unaffected limbs at very early stage of experiment local focus ischemic brain damage in rats.Method:Thirty SD rats with middle cerebral artery occlusion (MCAO) were randomly divided into EA on unaffected limbs group(HT) or affected limbs group(DT), and control group (MC) 10 rats in each group. Another10rats was set as sham operation control group (OC). EA groups received EA on the accupoints of Quchi (LI 11)and Neiguan (PC6) on forelimb, and Zusanli (ST36) and Xiajuxu (ST39) on hindlimb. EA was given with opposing needle(ju ci) method, cross stimulation at left and right side, at 3mA, in cycles of (loose/dense)10Hz:50Hz/5s:10s, 15min per session, once a day, 7 sessions per week. Infarction volume of the brain was calculated by TTCdying and photoshop IPP analyses. Neurological scores were evaluated by modified neurological severity score(mNSS) method at day 3, 7, 14 and 21 post-MCAO.Result:The mNSS scores in HT group was lower than that of MC group at day 3 (P0.05); At day 7 and 14,the scores in both EA groups were lower than that of MC group (P0.01) and also significant differences werefound between both EA groups(P0.01). The mNSS scores in both EA groups were almost returned to the level ofOC group at day 21 and much lower than that of MC group(P0.01). The infarction volume in HT group wasless than that in DT group, while that in both EA groups was lower than that in MC group(P0.05).Conclusion:EA on unaffected limbs at very early stage after stroke had greater beneficial effect in facilitating neurological function recovery and allviating the infarction volume of brain, compared to that on affected limbs.

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电针对大鼠脑局灶性缺血早期未受影响肢体的影响

目的:探讨针刺治疗对实验性局部局灶性缺血性脑损伤早期正常肢体的影响。方法:将30只大脑中动脉闭塞(MCAO) SD大鼠随机分为未患肢EA组(HT)和患肢EA组(DT)，每组10只，对照组(MC)。另取10只大鼠作为假手术对照组(OC)。EA组分别在前肢曲池穴(LI 11)、内关穴(PC6)和后肢足三里穴(ST36)、下巨虚穴(ST39)进行EA治疗。采用对针(菊针)法，左右交叉刺激，电流3mA，(松/密)10Hz:50Hz/5s:10s周期，每次15min，每天1次，每周7次。采用TTCdying和photoshop IPP分析计算脑梗死体积。在mcao后第3、7、14、21天采用改良神经系统严重程度评分法(mNSS)评估神经系统评分。结果:第3天HT组mNSS评分低于MC组(P0.05);第7天和第14天，EA组和EA组的评分均低于MC组(P0.01)， EA组和EA组之间差异有统计学意义(P0.01)。在第21天，EA组和EA组的mNSS评分基本恢复到oc组的水平，显著低于MC组(P0.01)。HT组梗死体积小于DT组，EA组梗死体积均小于MC组(P0.05)。结论:脑卒中后早期对未患肢进行电休克治疗，在促进神经功能恢复和减轻脑梗死体积方面比对患肢进行电休克治疗更有利。

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来源期刊

中国康复医学杂志 Medicine-Rehabilitation

CiteScore

0.30

自引率

0.00%

发文量

9621

期刊介绍： Chinese Journal of Rehabilitation Medicine is a national professional core journal sponsored by the Chinese Society of Rehabilitation Medicine. It is openly circulated at home and abroad. The contents are mainly related to the rehabilitation treatment of motor system and related advanced nerve center dysfunction, cardiorespiratory dysfunction and so on. It has been successively included in China Science and Technology Journal Management Database and China Biomedical Literature CD-ROM Database. In January 1996, it became one of the first selected journals of China Academic Journals (CD-ROM Edition) co-sponsored by Beijing Tsinghua Information System Engineering Company, the National Engineering Center of CD-ROM Edition, and in 1998, it was selected as an online scientific and technological journal by China Institute of Scientific and Technological Information and can be accessed instantly on the international Internet. The full text can be accessed instantly on the Internet.