Zinc supplementation in neonatal bronchopulmonary dysplasia: Is it beneficial?

Current Pediatric Research Pub Date : 2021-01-01 DOI:10.35841/0971-9032.25.7.652-656

M. Elfarargy, D. Ali, G. Al-Ashmawy, Haidy Khattab

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Abstract

Background: Neonatal Broncho Pulmonary Dysplasia (BPD) is a chronic chest disease that is caused by prolonged ventilation and oxygenation, leading to sever neonatal disability. Patients and methods: Prospective Randomized Clinical Trial (RCT) study which was done at Tanta University Hospital (TUH) from July 2016 to March 2018 on 100 preterm neonates who had Respiratory Distress (RD) and were put on Mechanical Ventilation (MV). The studied neonates were divided into 2 groups: group 1, which received Zn supplementation, and group 2, which received placebo. Urinary β2-microglobulin (B2M) and serum Krebs van den Lungen-6 (KL-6) levels were estimated on the 3rd day and the10th day of presence in the hospital. Results: Significant decline in urinary B2M and serum KL-6 levels occurred in neonates of group 1 who were given Zn compared with those in group 2 neonates, who received placebo (P<0.05). There was a significant decline in the time of incubator stay in group 1 neonates, compared with that of group 2 neonates (P<0.05). Group 1 neonates showed a significant decline in the development of established cases of BPD if compared with group 2 (P<0.05). Conclusion: Zn supplementation is beneficial in the prevention of neonatal BPD.

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补充锌治疗新生儿支气管肺发育不良:是否有益?

背景:新生儿支气管肺发育不良(BPD)是一种慢性胸部疾病，由长时间通气和氧合引起，可导致新生儿严重残疾。患者与方法:2016年7月至2018年3月在坦塔大学附属医院(TUH)对100例呼吸窘迫(RD)并采用机械通气(MV)的早产儿进行前瞻性随机临床试验(RCT)研究。将所研究的新生儿分为2组:1组给予补锌，2组给予安慰剂。在入院第3天和第10天测定尿β2-微球蛋白(B2M)和血清克雷伯斯-范登伦根-6 (KL-6)水平。结果:1组新生儿给予锌后尿B2M和血清KL-6水平明显低于对照组(P<0.05)。1组新生儿保温箱停留时间显著低于2组(P<0.05)。与2组相比，1组新生儿的BPD发病率显著下降(P<0.05)。结论:补充锌有助于预防新生儿BPD。

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来源期刊

Current Pediatric Research Medicine-Pediatrics, Perinatology and Child Health

自引率

0.00%

发文量

145

期刊介绍： Current Pediatric Research is an interdisciplinary Research Journal for publication of original research work in all major disciplines of Pediatric Research. The objective of the journal is to provide a scientific communication medium to discuss the utmost advancements in the domain of Pediatric Research. This journal aims to assemble and reserve precise, specific, detailed data on this immensely diversified subject. Current Pediatric Research is scientific open access journal that specifies the development activities conducted in the field of pediatric research. This journal encompasses the study related to different diversified aspects in pediatric research such as Pediatric Nursing, pediatric emergency care, pediatric nephrology, pediatric pulmonology, pediatric psychology, pediatric dental care, pediatric diabetes, pediatric stroke, pediatric healthcare, pediatric congenital heart disease, pediatric trauma and many more relevant fields.