Effect of repetitive transcranial magnetic stimulation on mood in healthy subjects

V. Moulier, C. Gaudeau-Bosma, C. Isaac, A. Allard, N. Bouaziz, D. Sidhoumi, S. Braha-Zeitoun, R. Benadhira, F. Thomas, D. Januel
{"title":"Effect of repetitive transcranial magnetic stimulation on mood in healthy subjects","authors":"V. Moulier, C. Gaudeau-Bosma, C. Isaac, A. Allard, N. Bouaziz, D. Sidhoumi, S. Braha-Zeitoun, R. Benadhira, F. Thomas, D. Januel","doi":"10.3402/snp.v6.29672","DOIUrl":null,"url":null,"abstract":"Background High frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) has shown significant efficiency in the treatment of resistant depression. However in healthy subjects, the effects of rTMS remain unclear. Objective Our aim was to determine the impact of 10 sessions of rTMS applied to the DLPFC on mood and emotion recognition in healthy subjects. Design In a randomised double-blind study, 20 subjects received 10 daily sessions of active (10 Hz frequency) or sham rTMS. The TMS coil was positioned on the left DLPFC through neuronavigation. Several dimensions of mood and emotion processing were assessed at baseline and after rTMS with clinical scales, visual analogue scales (VASs), and the Ekman 60 faces test. Results The 10 rTMS sessions targeting the DLPFC were well tolerated. No significant difference was found between the active group and the control group for clinical scales and the Ekman 60 faces test. Compared to the control group, the active rTMS group presented a significant improvement in their adaptation to daily life, which was assessed through VAS. Conclusion This study did not show any deleterious effect on mood and emotion recognition of 10 sessions of rTMS applied on the DLPFC in healthy subjects. This study also suggested a positive effect of rTMS on quality of life.","PeriodicalId":90343,"journal":{"name":"Socioaffective neuroscience & psychology","volume":"6 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3402/snp.v6.29672","citationCount":"17","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Socioaffective neuroscience & psychology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3402/snp.v6.29672","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 17

Abstract

Background High frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) has shown significant efficiency in the treatment of resistant depression. However in healthy subjects, the effects of rTMS remain unclear. Objective Our aim was to determine the impact of 10 sessions of rTMS applied to the DLPFC on mood and emotion recognition in healthy subjects. Design In a randomised double-blind study, 20 subjects received 10 daily sessions of active (10 Hz frequency) or sham rTMS. The TMS coil was positioned on the left DLPFC through neuronavigation. Several dimensions of mood and emotion processing were assessed at baseline and after rTMS with clinical scales, visual analogue scales (VASs), and the Ekman 60 faces test. Results The 10 rTMS sessions targeting the DLPFC were well tolerated. No significant difference was found between the active group and the control group for clinical scales and the Ekman 60 faces test. Compared to the control group, the active rTMS group presented a significant improvement in their adaptation to daily life, which was assessed through VAS. Conclusion This study did not show any deleterious effect on mood and emotion recognition of 10 sessions of rTMS applied on the DLPFC in healthy subjects. This study also suggested a positive effect of rTMS on quality of life.
反复经颅磁刺激对健康受试者情绪的影响
背景高频重复经颅磁刺激(rTMS)对左背外侧前额叶皮层(DLPFC)治疗难治性抑郁症有显著的疗效。然而,在健康受试者中,rTMS的效果尚不清楚。我们的目的是确定10次rTMS应用于DLPFC对健康受试者情绪和情绪识别的影响。在一项随机双盲研究中,20名受试者每天接受10次主动(10hz频率)或假rTMS。经颅磁刺激线圈通过神经导航定位于左侧DLPFC。使用临床量表、视觉模拟量表(VASs)和Ekman 60面部测试,在基线和rTMS后评估情绪和情绪处理的几个维度。结果针对DLPFC的10次rTMS治疗耐受良好。在临床量表和Ekman 60面部测试中,治疗组与对照组无显著差异。与对照组相比,积极的rTMS组在日常生活适应方面有显著改善,通过VAS评估。结论10次rTMS对健康受试者DLPFC的情绪和情绪识别无不良影响。本研究也提示rTMS对生活质量有积极的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信