Comparative study of brain function tests between patients with schizophrenia and normal controls

国际医药卫生导报 Pub Date : 2014-12-15 DOI:10.3760/CMA.J.ISSN.1007-1245.2014.24.002

L. Bai, H. Gao, Yan Wang, Zhao Zhao, Rui-li Wang, Feng Guo, Yuxiang Jiao

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Abstract

Objective To investigate differences in brain function tests between patients with schizophrenia and normal controls.Methods 80 patients who met diagnostic criteria for schizophrenia of International Classification of Diseases (10th edition) received brain function tests,for the same period 52 cases of normal control also received brain function tests.Test results were compared to analyze differences in brain neurotransmitters.Results There were statistically significant differences in GABA and Glu neurotransmitters power between schizophrenia group and normal control group (t =-1.991,P =0.049; t =-2.228,P =0.028).There was statistically significant difference in glutamate neurotransmitter relative power between two groups (t =-2.115,P =0.036).There was statistically significant difference in neurotransmitters total power between two groups (t =-2.631,P =0.010).Conclusion Glutamate neurotransmitter power,relative neurotransmitters power and total neurotransmitters power in schizophrenia group were higher than those in normal control group,which suggested abnormal brain neurotransmitters function in patients with schizophrenia. Key words: Schizophrenia; Normal control group; Brain function tests

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精神分裂症患者与正常人脑功能测试的比较研究

目的探讨精神分裂症患者脑功能指标与正常人的差异。方法对80例符合《国际疾病分类(第十版)》精神分裂症诊断标准的患者进行脑功能检查，同期对52例正常对照患者进行脑功能检查。对比测试结果，分析脑神经递质的差异。结果精神分裂症组与正常对照组GABA、Glu神经递质功率比较，差异有统计学意义(t =-1.991,P =0.049;t =-2.228,P =0.028)。两组间谷氨酸神经递质相对功率比较，差异有统计学意义(t =-2.115,P =0.036)。两组间神经递质总功率比较，差异有统计学意义(t =-2.631,P =0.010)。结论精神分裂症组谷氨酸神经递质功率、相对神经递质功率和总神经递质功率均高于正常对照组，提示精神分裂症患者脑神经递质功能异常。关键词:精神分裂症;正常对照组;脑功能测试

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国际医药卫生导报

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