Expression and significance of interleuk-17 in peripheral blood of patients with severe pnemonia

Abstract

Objective To investigate the expression and connotation of peripheral interleuk-17(IL-17) in patients with severe pnemonia.Methods A total of 56 cases with severe pneumonia were selected in our hospital from June 2013 to June 2014 and were grouped according to Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE IⅡ) scores,patients with lower APACHE Ⅱ score (＜ 20) were divided into group A,otherwise they were included in group B.30 healthy individuals were served as control group.ELISA was utilized to detect the concentrations of IL-17 in peripheral blood of each group and relevant comparative analysis was applied to compare the differences between the groups.Results Level of peripheral IL-17 was significantly increased in patients with severe pneumonia compared with that of control group (P ＜ 0.05).Furthermore,expression of IL-17 increased more significantly in patients with higher APACHE Ⅱ score compared with the lower score group (P ＜ 0.05).Conclusion Patients with severe pneumonia have high expression of IL-17 and the degree of increase is related to the severity of the disease.This study suggests that IL-17 may play a crucial role in the onset and progress of severe pneumonia. Key words: Interleuk-17;  Severe pneumonia;  Acute physiology and chronic health evaluation Ⅱ