Impact of lipoic acid on lesion density and surrounding edema of patients with acute cerebral infarction

国际医药卫生导报 Pub Date : 2014-11-15 DOI:10.3760/CMA.J.ISSN.1007-1245.2014.22.004

Rongping Chen, Juanjuan Wu, Haifeng Song, J. Ren, W. Mo, Jiyun Feng, Hong Deng

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Abstract

Objective To discuss and analyze the impact of lipoic acid on lesion density and surrounding edema of patients with acute cerebral infarction (ACI).Methods 60 patients with ACI in our hospital from March 2012 to March 2014 were chosen and divided into two groups with 30 cases in each group according to random single-blind principle.Control group was treated with routine treatment,while observation group was treated with intravenous drip of lipoic acid injection on the basis of routine treatment.Clinical effect,lesions and surrounding edema area change and adverse drug reaction of two groups were compared.Results The effective rate of observation group was obviously higher than that of control group (86.7％ vs.60.0％).On the 7th day of treatment,CT value of observation group obviously increased,and lesions and edema area obviously decreased; CT value of control group obviously decreased,and lesions and edema area obviously increased; CT value of observation group was obviously higher than that of control group,and lesions and edema area were obviously smaller than those of control group (P ＜ 0.05).Conclusion Lipoic acid has a good curative effect in the treatment of ACI,which can effectively improve CT value,improve relative area without lesion and decrease edema area,so it is safe and reliable. Key words: Lipoic acid; Acute cerebral infarction; Lesions; Edema

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硫辛酸对急性脑梗死患者病灶密度及周围水肿的影响

目的探讨分析硫辛酸对急性脑梗死(ACI)患者病灶密度及周围水肿的影响。方法选择2012年3月~ 2014年3月我院收治的急性脑损伤患者60例，按随机单盲原则分为两组，每组30例。对照组患者给予常规治疗，观察组患者在常规治疗的基础上静脉滴注硫辛酸注射液。比较两组患者的临床疗效、病灶及周围水肿面积变化及药物不良反应。结果观察组有效率明显高于对照组(86.7% vs.60.0%)。治疗第7天，观察组CT值明显升高，病变及水肿面积明显减小;对照组CT值明显降低，病变及水肿面积明显增大;观察组患者CT值明显高于对照组，病变及水肿面积明显小于对照组(P < 0.05)。结论硫辛酸治疗ACI疗效良好，可有效提高CT值，提高相对无损面积，减少水肿面积，安全可靠。关键词:硫辛酸;急性脑梗死;病变;水肿

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国际医药卫生导报

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