Relationship between serum high sensitive C-reactive protein and vascular dysfunction in hemodialysis patients

中国综合临床 Pub Date : 2020-01-01 DOI:10.3760/CMA.J.ISSN.1008-6315.2020.01.013

Z. Xin, Shen Zhan, Lihong Zhang

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Abstract

Objective To explore the relationship between high sensitivity C-reactive protein (hs-CRP) and vascular access failure in hemodialysis patients. Methods From July 2017 to June 2018, 105 patients with regular hemodialysis were selected from the blood purification center of Beijing Haidian hospital.According to the presence or absence of VAF, the patients were divided into two groups: VAF+ group and VAF - group.The difference of hs CRP level between the two groups was compared. Results During the 12-month follow-up, 17 patients had more than one event of vascular failure.The total protein level of VAF+ group was significantly lower than that of VAF-Group((65.61±4.01) g/L and( 68.98±5.66) g/L, P=0.021). The male proportion of VAF+ group was lower than that of VAF-group (29.41% vs 53.41%, P=0.07), but the difference was not statistically significant.There was no significant difference in the annual change level of hs CRP between VAF + group and VAF Group((0.33±5.49) mg/L and(0.57±4.45) mg/L, P=0.840). The level of total protein was the independent protective factor of VAF(OR=0.889, 95%CI 0.797-0.991, P=0.034). The level of hs CRP was not significantly correlated with vascular access events(OR=1.018, 95%CI 0.926-1.119, P=0.713). Conclusion There is no correlation between hs CRP and VAF.The exact mechanism of inflammation in intimal hyperplasia needs further study. Key words: Hemodialysis; Hypersensitive C-reactive protein; Vascular access failure; Total protein

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血液透析患者血清高敏c反应蛋白与血管功能障碍的关系

目的探讨高敏c反应蛋白(hs-CRP)与血液透析患者血管通路衰竭的关系。方法选取2017年7月~ 2018年6月北京海淀医院血液净化中心常规血液透析患者105例。根据有无VAF分为VAF+组和VAF -组。比较两组患者hs CRP水平的差异。结果随访12个月，17例患者发生1次以上血管衰竭。VAF+组总蛋白水平显著低于VAF-组((65.61±4.01)g/L和(68.98±5.66)g/L, P=0.021)。VAF+组男性比例低于VAF-组(29.41% vs 53.41%， P=0.07)，但差异无统计学意义。VAF +组和VAF组hs CRP年变化水平((0.33±5.49)mg/L和(0.57±4.45)mg/L, P=0.840)差异无统计学意义。总蛋白水平是VAF的独立保护因素(OR=0.889, 95%CI 0.797-0.991, P=0.034)。hs CRP水平与血管通路事件无显著相关性(OR=1.018, 95%CI 0.926-1.119, P=0.713)。结论hs CRP与VAF无相关性。炎症在内膜增生中的确切机制有待进一步研究。关键词:血液透析;超敏c反应蛋白;血管通路失败;血清总蛋白

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来源期刊

中国综合临床

CiteScore

0.10

自引率

0.00%

发文量

16855

期刊介绍： Clinical Medicine of China is an academic journal organized by the Chinese Medical Association (CMA), which mainly publishes original research papers, reviews and commentaries in the field. Clinical Medicine of China is a source journal of Peking University (2000 and 2004 editions), a core journal of Chinese science and technology, an academic journal of RCCSE China Core (Extended Edition), and has been published in Chemical Abstracts of the United States (CA), Abstracts Journal of Russia (AJ), Chinese Core Journals (Selection) Database, Chinese Science and Technology Materials Directory, Wanfang Database, China Academic Journal Database, JST Japan Science and Technology Agency Database (Japanese) (2018) and other databases.