Efficacy and safety evaluation of magnesium aluminate, lansoprazole, amoxicillin and furazolidone in the treatment of Helicobacter pylori-related gastric ulcer

中国综合临床 Pub Date : 2020-01-01 DOI:10.3760/CMA.J.ISSN.1008-6315.2020.01.006

Hongwei Liu, Yujie Huang, Jianying Yang, Guocun Peng, Shao-min Song, Liyun Wang

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Abstract

Objective To investigate the efficacy and safety of magnesium aluminium carbonate, lansoprazole, amoxicillin and furazolidone in the treatment of Helicobacter pylori-related gastric ulcer. Methods From March 2016 to December 2017, 120 patients with HP related gastric ulcer who met the inclusion criteria were enrolled in the digestive department of Linxi Hospital of Kailuan general hospital.They were divided into observation group and control group with random number table method, 60 cases in each group.The control group was given lansoprazole+ amoxicillin+ furazolidone triple therapy.On this basis, the observation group was added with magnesium aluminum carbonate.The clinical efficacy, clearance rate of Helicobacter pylori, the level of VEGF and EGF in gastric juice were compared between the two groups. Results The total clinical effective rate of the observation group was 95.0% (57/60), which was significantly higher than that of the control group (83.3%) (50/60). The difference between the two groups was statistically significant (χ2=4.23, P 0.05). Conclusion The treatment of Helicobacter pylori related gastric ulcer with the combination of aluminum carbonate, lansoprazole, amoxicillin and furazolidone can obviously improve the clinical symptoms and promote the regeneration of ulcer mucosa. Key words: Helicobacter pylori; Gastric Ulcer; Magnesium aluminium carbonate; Lansoprazole; Amoxicillin; Furazolidone

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铝酸镁、兰索拉唑、阿莫西林和呋喃唑酮治疗幽门螺杆菌相关性胃溃疡的疗效和安全性评价

目的探讨碳酸铝镁、兰索拉唑、阿莫西林和呋喃唑酮治疗幽门螺杆菌相关性胃溃疡的疗效和安全性。方法选取2016年3月至2017年12月开滦总医院临西医院消化科符合纳入标准的HP相关胃溃疡患者120例。采用随机数字表法将患者分为观察组和对照组，每组60例。对照组患者给予兰索拉唑+阿莫西林+呋喃唑酮三联治疗。在此基础上，观察组添加碳酸镁铝。比较两组患者的临床疗效、幽门螺杆菌清除率、胃液中VEGF、EGF水平。结果观察组临床总有效率为95.0%(57/60)，显著高于对照组(83.3%)(50/60)。两组比较差异有统计学意义(χ2=4.23, p0.05)。结论碳酸铝、兰索拉唑、阿莫西林、呋喃唑酮联合治疗幽门螺杆菌相关性胃溃疡可明显改善临床症状，促进溃疡粘膜的再生。关键词:幽门螺杆菌;胃溃疡;碳酸镁铝;Lansoprazole;阿莫西林;呋喃唑酮

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来源期刊

中国综合临床

CiteScore

0.10

自引率

0.00%

发文量

16855

期刊介绍： Clinical Medicine of China is an academic journal organized by the Chinese Medical Association (CMA), which mainly publishes original research papers, reviews and commentaries in the field. Clinical Medicine of China is a source journal of Peking University (2000 and 2004 editions), a core journal of Chinese science and technology, an academic journal of RCCSE China Core (Extended Edition), and has been published in Chemical Abstracts of the United States (CA), Abstracts Journal of Russia (AJ), Chinese Core Journals (Selection) Database, Chinese Science and Technology Materials Directory, Wanfang Database, China Academic Journal Database, JST Japan Science and Technology Agency Database (Japanese) (2018) and other databases.