Clinical characteristic analysis of 5 patients with confirmed Ebola virus disease

Q4 Medicine

第二军医大学学报 Pub Date : 2015-01-01 DOI:10.3724/SP.J.1008.2015.00584

Fu-xiang Li, Cheng-zhong Li, F. Zhou, Zong-hai Hu, Zhi-hui Chen, C. Hao, Jian-Jun Yang, Chang-xing Guo, Ping Zhang, Ying Cai, Wangang Guo, J. Yin

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引用次数: 0

Abstract

Objective To analyze the clinical characteristics and prognoses of patients with confirmed Ebola virus disease(EVD)and to summarize the clinical treatment experience.Methods The epidemiologic history,symptoms,signs,treatment,and prognoses of 5confirmed EVD cases were summarized.And the relationship between clinical features and clinical outcomes was analyzed.Results The 5patients,2 men and 3women,ranged in age from 32-58 years old,with a median age of 46.Three were severe cases when they were admitted while the others were relatively mild.All the patients admitted the exposure history within 21 days before onset of the symptoms,with two patients(one medical staff)from the same transmission chain.The main symptoms included fever,weakness or fatigue,lack of appetite,diarrhea and red eyes,with one patient having gastrointestinal bleeding.The first test of PCR Ebola virus(EBOV)RNA was positive in all the 5cases.They were promptly isolated and treated with antipyretic and fluid replacement therapy.Meanwhile,prevention of complications and treatment of basic diseases were also conducted.Three patients survived at last and the other two died.Conclusion Prompt isolation of the infection source and tracing the contacts can effectively prevent the transmission of EVD.PCR assay is an effective,rapid and simple method to diagnose EVD.Early supporting treatment-centered multimodality therapy can improve the treatment outcome of EVD.

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确诊埃博拉病毒病5例临床特征分析

目的分析确诊埃博拉病毒病(EVD)患者的临床特点及预后，总结临床治疗经验。方法总结5例EVD确诊病例的流行病学史、症状、体征、治疗及预后。并分析临床特征与临床转归的关系。结果5例患者，男2例，女3例，年龄32 ~ 58岁，中位年龄46岁。其中三人入院时病情严重，其他人病情相对较轻。所有患者均承认在发病前21天内有接触史，其中2例患者(1名医务人员)来自同一传播链。主要症状包括发热、虚弱或疲劳、食欲不振、腹泻和眼睛发红，1例患者出现胃肠道出血。5例患者首次PCR检测埃博拉病毒(EBOV)RNA均为阳性。他们被及时隔离并给予退热和补液治疗。同时进行并发症的预防和基础疾病的治疗。3名病人最终幸存下来，另外2人死亡。结论及时隔离传染源和追踪接触者可有效预防埃博拉病毒病的传播。PCR检测是诊断埃博拉病毒病有效、快速、简便的方法。早期支持以治疗为中心的多模式治疗可改善埃博拉病毒病的治疗效果。

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来源期刊

第二军医大学学报 Medicine-Medicine (all)

CiteScore

0.50

自引率

0.00%

发文量

14752

期刊介绍： Founded in 1980, Academic Journal of Second Military Medical University(AJSMMU) is sponsored by Second Military Medical University, a well-known medical university in China. AJSMMU is a peer-reviewed biomedical journal,published in Chinese with English abstracts.The journal aims to showcase outstanding research articles from all areas of biology and medicine,including basic medicine(such as biochemistry, microbiology, molecular biology, genetics, etc.),clinical medicine,public health and epidemiology, military medicine,pharmacology and Traditional Chinese Medicine),to publish significant case report, and to provide both perspectives on personal experiences in medicine and reviews of the current state of biology and medicine.