An integrative toy model of cell flattening, spreading, and ruffling.

IF 1 4区医学 Q4 BIOPHYSICS

Biorheology Pub Date : 2016-02-10 DOI:10.3233/BIR-14042

M. Herant, M. Dembo

引用次数: 1

Abstract

BACKGROUND The processes of cell spreading and crawling are frequently associated with mysterious waves and ruffling cycles of the leading edge. OBJECTIVE To develop a physical model that can account for these phenomena based on a few simple and plausible rules governing adhesion, contractility, polymerization of cytoskeleton, and membrane tension. METHODS Extension of a continuum mechanical model of phagocytosis [J Cell Sci. (2006);119(Pt 9):1903-13] adding a simple coupling between membrane curvature and cytoskeletal polymerization. RESULTS We show that our generalized model has just the right nonlinearity needed for triggering of stochastic/chaotic cycles of ruffling similar to those that are observed in real cells. CONCLUSIONS The cycles are caused by a branching instability at the leading edge that leads to bifurcations of protrusion into forward moving lamellipodium and upward and rearward folding ruffles. The amplitude of the instability is modulated by the surface tension, with higher tension stabilizing against ruffling (but inhibiting protrusion) and lower tension promoting ruffling and protrusion.

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一个完整的玩具模型，细胞变平、扩散和褶皱。

细胞的扩散和爬行过程经常与前缘的神秘波浪和褶皱循环有关。目的建立一个物理模型，根据一些简单而合理的规则来解释这些现象，这些规则控制着粘附性、收缩性、细胞骨架的聚合和膜张力。方法:一种连续力学模型的建立[J]。(2006);119(Pt 9):1903-13)添加膜曲率和细胞骨架聚合之间的简单耦合。结果我们表明，我们的广义模型具有与在真实细胞中观察到的相似的触发随机/混沌皱褶周期所需的正确非线性。结论该循环是由前缘分支不稳定引起的，该分支不稳定导致突出分岔为向前移动的片叶基和向上和向后折叠的褶叶。不稳定性的幅度受表面张力的调节，高张力对起皱稳定(但抑制突出)，低张力促进起皱和突出。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biorheology 医学-工程：生物医学

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials. The scope of papers solicited by Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.