Quantitative Parameters Analysis for Prenatally Echocardiographic Diagnosis of Atrioventricular Septal Defects

IF 0.3 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Congenital Heart Disease Pub Date : 2023-01-01 DOI:10.32604/chd.2023.029060

Xiaoxue Zhou, Tingyang Yang, Yehui Zhang, Y. Ruan, Jiancheng Han, Xiaowei Liu, Ying Zhao, X. Gu, Tingting Liu, Hairui Wang, Yihua He

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Abstract

Background: Atrioventricular septal defects (AVSDs) are screened and diagnosed usually rely on the imaging characteristics of fetal echocardiography (FE). However, diagnosis on images is heavily depended on sonographers’ experience and the quantitative data are rarely studied. Objective: This study aimed to realize the prenatal diagnosis of AVSDs by analyzing the quantitative data on FE. Methods: One hundred and thirteen cardiac quantitative data was analyzed in 370 normal and 49 AVSDs fetuses retrospectively. The top six with the highest diagnostic accuracy rate were acquired according to the area under the curve (AUC), and the diagnostic value of six variables was analyzed. Results: Six parameters obtained on the four-chamber view (4CHV), including the atrial to ventricular length ratio in end-diastole (AVLR-ED), AVLR-ED combined with the atrial to ventricular length ratio in end-systole (AVLR-ES), quantile score (Q score) of AVLR-ED, Q score of AVLR-ES, Q score of ventricle length in end-diastole (VL-ED), and AVLR-ES, were the top six with the highest diagnostic value, and the AUC was 0.99 (95%CI 0.99–1.00), 0.99 (95%CI 0.99–1.00), 0.99 (95%CI 0.98–1.00), 0.95 (95%CI 0.91–0.99), 0.93 (95%CI 0.87–0.99), and 0.91 (95%CI 0.83–1.00), respectively. And within the 20% false positive rate, the diagnostic sensitivity was greater than 100%, 100%, 100%, 90%, 90%, and 88%, respectively. Conclusions: Six variables could be used for prenatal diagnosis of AVSDs. Among them, AVLR-ED and Q score of AVLR-ED, obtained on the 4CHV, were more convenient to acquire and had higher diagnostic accuracy.

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房室间隔缺损产前超声心动图定量参数分析

背景:房室间隔缺损(AVSDs)的筛查和诊断通常依赖于胎儿超声心动图(FE)的成像特征。然而，对图像的诊断在很大程度上依赖于超声医师的经验，定量数据的研究很少。目的:通过FE定量数据分析，实现AVSDs的产前诊断。方法:回顾性分析370例正常胎儿和49例avsd胎儿113例心脏定量资料。根据曲线下面积(AUC)获得诊断准确率最高的前6名，并分析6个变量的诊断价值。结果:在四室位(4CHV)上获得的6个参数，包括舒张末期心房与心室长度比(AVLR-ED)、AVLR-ED合并收缩期心房与心室长度比(AVLR-ES)、AVLR-ED分位数评分(Q评分)、AVLR-ED分位数评分(Q评分)、AVLR-ES、AVLR-ES是诊断价值最高的前6个参数，AUC分别为0.99 (95%CI 0.99 - 1.00)、0.99 (95%CI 0.99 - 1.00)、0.99 (95%CI 0.98-1.00)、0.99 (95%CI 0.98-1.00)。分别为0.95 (95%CI 0.91 - 0.99)、0.93 (95%CI 0.87-0.99)、0.91 (95%CI 0.83-1.00)。在20%假阳性率范围内，诊断敏感性分别大于100%、100%、100%、90%、90%、88%。结论:6个变量可用于AVSDs的产前诊断。其中，在4CHV上获得的AVLR-ED和AVLR-ED的Q评分更方便获取，诊断准确率更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Congenital Heart Disease CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

0.40

自引率

33.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Congenital Heart Disease is an open-access journal focusing on congenital heart disease in children and adults. Though the number of infants born with heart disease each year is relatively small (approximately 1% of the population), advances in treating such malformations have led to increased life spans for this population. Consequently, today most patients treated for congenital heart disease are over the age of 20. What are the special needs of adults with congenital heart disease? What are the latest developments in the care of the fetus, infants, and children? Who should treat these patients? How should they be treated? Congenital Heart Disease focuses on these questions and more. Conceived as a forum for the most up-to-date information on congenital heart disease, the journal is led by Editor-in-Chief Vladimiro L. Vida, MD, Ph.D., Professor in Cardiac Surgery, University of Padua in Italy, as well as an international editorial board. Congenital Heart Disease publishes articles on heart disease as it relates to the following areas: • Basic research of congenital heart disease • Clinical pediatric and adult cardiology • Cardiac imaging • Preventive cardiology • Diagnostic and interventional cardiac catheterization • Electrophysiology • Surgery • Long-term follow-up, particularly as it relates to older children and adult congenital heart disease • Exercise and exercise physiology in the congenital patient • Post-op and critical care • Common disorders such as syncope, chest pain, murmurs, as well as acquired disorders such as Kawasaki syndrome The journal includes clinical studies, invited editorials, state-of-the-art reviews, case reports, articles focusing on the history and development of congenital heart disease, and CME material. Occasional issues focus on special topics. Readership: Congenital Heart Disease was created for pediatric cardiologists; adult cardiologists who care for patients with congenital heart disease; pediatric and pediatric cardiology nurses; surgeons; radiologists; anesthesiologists; critical care physicians and nurses; and adult support staff involved in the care of patients with congenital heart disease.