Electroacupuncture Inhibits Inflammatory Response in Rats With Interstitial Cystitis

IF 0.2 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE

Acupuncture & Electro-Therapeutics Research Pub Date : 2021-01-01 DOI:10.3727/036012921x16258618048412

Ji-wei Feng, Wen Li, Jiandang Liu, Junsheng Hu, Zhi-hao Li, Xuehui Zhao, Yue-Lai Chen

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引用次数: 0

Abstract

OBJECTIVE: Electroacupuncture (EA) has been clinically utilized to manage interstitial cystitis (IC), but its related mechanism research is remained to be researched. This study aimed to explore the role of EA in inhibiting the inflammatory response of IC rats, and research the possible mechanism based on the changes of urodynamics, mast cell tryptase expression and the content of inflammatory substances. METHODS: EA (continuous wave, 30 Hz, 1 mA) was applied to stimulate the Ciliao point (BL32) and the Huiyang point (BL35) of rats. Changes of urodynamics, mast cell tryptase expression and the content of IL-6 and TNF-α were detected after 24 hours of the treatment. RESULTS: The results showed that after EA treatment, compared with the model group, the initial urination time of the rats was prolonged (3.23 ± 0.60 to 5.27 ± 0.27 min), the bladder capacity was increased (0.80 ± 0.15 to 1.31 ± 0.07 ml), and the degree of bladder mucosal damage was restored. The expression of mast cell tryptase, and the content of IL-6 and TNF-α in its bladder tissue and urine were reduced.CONCLUSION: These findings suggested that EA could suppress bladder overactivity and inhibit inflammatory response of IC rats, and its mechanism was proved to be related to the inhibition of mast cell degranulation and the down-regulation of inflammatory substances IL-6 and TNF-α in bladder tissue.

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电针抑制间质性膀胱炎大鼠炎症反应

目的:电针(EA)治疗间质性膀胱炎(IC)已被临床应用，但其相关机制尚待研究。本研究旨在探讨EA对IC大鼠炎症反应的抑制作用，并从尿动力学、肥大细胞胰蛋白酶表达及炎症物质含量的变化等方面探讨其可能的机制。方法:用EA(连续波，30 Hz, 1 mA)刺激大鼠睫状肌点(BL32)和回阳点(BL35)。治疗24 h后检测尿动力学、肥大细胞胰蛋白酶表达及IL-6、TNF-α含量的变化。结果:与模型组比较，EA治疗后大鼠初尿时间延长(3.23±0.60 ~ 5.27±0.27 min)，膀胱容量增加(0.80±0.15 ~ 1.31±0.07 ml)，膀胱黏膜损伤程度恢复。膀胱组织和尿液中肥大细胞胰蛋白酶表达降低，IL-6、TNF-α含量降低。结论:EA可抑制IC大鼠膀胱过度活动，抑制炎症反应，其机制可能与抑制膀胱肥大细胞脱颗粒、下调膀胱组织炎性物质IL-6、TNF-α有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acupuncture & Electro-Therapeutics Research 医学-全科医学与补充医学

CiteScore

0.50

自引率

66.70%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of the journal is to provide an international forum for the exchange of ideas and promotion of basic and clinical research in acupuncture, electro-therapeutics, and related fields. The journal was established in order to make acupuncture and electro-therapeutics a universally acceptable branch of medicine through multidisciplinary research based on scientific disciplines. The final goal is to provide a better understanding of both the beneficial and adverse effects of these treatments in order to supplement or improve existing methods of diagnosis, prognosis, treatment, and prevention of diseases in both Western and Oriental medicine.