Anti-diabetic Effect of Syzygium cumini leaves on Induced diabetic Rats

Abstract

The effect of different concentrations 1.5, 3, 4.5, 6 and 7.5% Syzygium cumini leaves as powder of Syzygium cumini on diabetes rats were evaluated thirty five male rats was purchased from Vaccine and Immunity Organization, and kept for 7 days on basal diet (Adaptation period), After adaptation period, the 35 rats were classified into two main groups; 5 rats in a normal group and 30 rats in a treated group. Diabetes was induced via injection of the infected rats with alloxan (150 mg/kg BW). To ascertain the induction of diabetes mellitus blood samples, were obtained from rats and blood glucose was determined. All diabetic rats were classified into the following group (5 rat each group): The control negative and control positive were fed on basal diet, as well as, the third, fourth, fifth, sixth and seventh groups fed standard diet had contained 1.5,3.0,4.5,6.0 and 7.5% Syzygium cumini leaves powder respectively for 28 day after injection. At the end of experimental period, the results showed that the lowest value glucose recorded for sixth group fed on Syzygium cumini powder (6%) with significant difference The highest cholesterol and triglycerides levels recorded for third group fed on Syzygium cumini powder (1.5%) while, the lowest value recorded for Seventh group fed on Syzygium cumini powder (7.5%) with significant difference. From the results, it could be recommended that leaves of Syzygium cumini is effective in improving lipid metabolism and preventing diabetic in diabetic rats.