Effect of 5-Aminolevulinic Acid Photodynamic Therapy Combined with Carbon dioxide Laser on Condyloma Acuminatum

IF 0.4 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Xiaolei Xie, Huajie Zhong, Shunli Tang, Yuan-Hong Wu, Xu Xu, Cong Zhu
{"title":"Effect of 5-Aminolevulinic Acid Photodynamic Therapy Combined with Carbon dioxide Laser on Condyloma Acuminatum","authors":"Xiaolei Xie, Huajie Zhong, Shunli Tang, Yuan-Hong Wu, Xu Xu, Cong Zhu","doi":"10.36468/pharmaceutical-sciences.spl.681","DOIUrl":null,"url":null,"abstract":"By comparing 5-aminolevulinic acid photodynamic therapy combined with carbon dioxide laser and carbon dioxide laser therapy only, to explore the therapeutic effect of 5-aminolevulinic acid photodynamic therapy combined with carbon dioxide laser on perianal and anal canal condyloma acuminatum. A total of 74 patients with perianal and anal canal condyloma acuminatum who were admitted to our hospital from January 2021 to December 2021 were selected as the research objects. They were randomly assigned to the observation group and the control group, with 37 cases in each group. The observation group was treated with 5-aminolevulinic acid photodynamic therapy combined with carbon dioxide laser and the control group was treated with carbon dioxide laser therapy. Both groups were treated once a week for 3 w. The therapeutic effect, recurrence rate and adverse reactions were compared between the two groups. The cure rate of condyloma acuminatum in the observation group was 86.48 %, which was higher than 54.05 % in the control group, with statistical significance (p<0.05). After follow-up, it was found that the recurrence rate of the observation group (13.51 %) was significantly lower than that of the control group (43.24 %), with statistical significance (p<0.05). The incidence of superficial scar and perianal pain in the observation group was 27.03 % and 21.62 % respectively, which was not significantly different from 35.14 % and 29.73 % in the control group. 5-aminolevulinic acid photodynamic therapy combined with carbon dioxide laser in the treatment of perianal and anal canal condyloma acuminatum has the advantages of good curative effect and low recurrence rate, which is worthy of clinical promotion.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Pharmaceutical Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.36468/pharmaceutical-sciences.spl.681","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

Abstract

By comparing 5-aminolevulinic acid photodynamic therapy combined with carbon dioxide laser and carbon dioxide laser therapy only, to explore the therapeutic effect of 5-aminolevulinic acid photodynamic therapy combined with carbon dioxide laser on perianal and anal canal condyloma acuminatum. A total of 74 patients with perianal and anal canal condyloma acuminatum who were admitted to our hospital from January 2021 to December 2021 were selected as the research objects. They were randomly assigned to the observation group and the control group, with 37 cases in each group. The observation group was treated with 5-aminolevulinic acid photodynamic therapy combined with carbon dioxide laser and the control group was treated with carbon dioxide laser therapy. Both groups were treated once a week for 3 w. The therapeutic effect, recurrence rate and adverse reactions were compared between the two groups. The cure rate of condyloma acuminatum in the observation group was 86.48 %, which was higher than 54.05 % in the control group, with statistical significance (p<0.05). After follow-up, it was found that the recurrence rate of the observation group (13.51 %) was significantly lower than that of the control group (43.24 %), with statistical significance (p<0.05). The incidence of superficial scar and perianal pain in the observation group was 27.03 % and 21.62 % respectively, which was not significantly different from 35.14 % and 29.73 % in the control group. 5-aminolevulinic acid photodynamic therapy combined with carbon dioxide laser in the treatment of perianal and anal canal condyloma acuminatum has the advantages of good curative effect and low recurrence rate, which is worthy of clinical promotion.
5-氨基乙酰丙酸光动力疗法联合二氧化碳激光治疗尖锐湿疣疗效观察
通过对比5-氨基乙酰丙酸光动力疗法联合二氧化碳激光与单纯二氧化碳激光治疗,探讨5-氨基乙酰丙酸光动力疗法联合二氧化碳激光治疗肛周、肛管尖锐湿疣的疗效。选取2021年1月至2021年12月在我院住院的74例肛周及肛管尖锐湿疣患者作为研究对象。随机分为观察组和对照组,每组37例。观察组患者采用5-氨基乙酰丙酸光动力治疗联合二氧化碳激光治疗,对照组患者采用二氧化碳激光治疗。两组患者均每周治疗1次,连续治疗3w。比较两组患者的治疗效果、复发率及不良反应。观察组尖锐湿疣治愈率为86.48%,高于对照组的54.05%,差异有统计学意义(p<0.05)。随访发现,观察组复发率(13.51%)显著低于对照组(43.24%),差异有统计学意义(p<0.05)。观察组浅表瘢痕和肛周疼痛发生率分别为27.03%和21.62%,与对照组的35.14%和29.73%差异无统计学意义。5-氨基乙酰丙酸光动力疗法联合二氧化碳激光治疗肛周、肛管尖锐湿疣,疗效好,复发率低,值得临床推广。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
审稿时长
2 months
期刊介绍: The Indian Journal of Pharmaceutical Sciences (IJPS) is a bi-monthly Journal, which publishes original research work that contributes significantly to further the scientific knowledge in Pharmaceutical Sciences (Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Therapeutics, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Pharmacovigilance, Pharmacoepidemiology, Pharmacoeconomics, Drug Information, Patient Counselling, Adverse Drug Reactions Monitoring, Medication Errors, Medication Optimization, Medication Therapy Management, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest). The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on current topics in Pharmaceutical Sciences are also considered for publication by the Journal.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信