Hemocytopoiesis and microelements metabolism’s indices in calves under the infl uence of national vitamin-amino-acid complex

Андрій Юрійович Мельник, A. Melnyk, Василь Михайлович Безух, Vasyl Bezukh, Олександр Миколайович Дубін, O. Dubin, Валерій Петрович Москаленко, V. Moskalenko, Наталія Володимирівна Вовкотруб, N. Vovkotrub, Леонід Мечиславович Богатко, Leonid Bogatko, Михайло Ярославович Тишківський, Mуkhailo Тyshkivskіy
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引用次数: 1

Abstract

In Ukrainian veterinary medicine the study of the eff ectiveness of new complex drugs remains relevant. The eff ect of the vitamin-mineral complex "Alphabet for Animals" on the state of hemocytopoiesis and the microelements metabolism in calves of 1.5‒2.5 months of age were studied. The composition of this drug includes the biologically active substances: vitamins A, D3, E, B1, B3, B5, B6, B12, K3 and essential amino-acids: DL-methionine, L-lysine and arginine. It is used in farm animals and poultry for the normalization of hemocytopoiesis, the prevention and treatment of vitamins and trace elements metabolism’s disorders. In the fi rst week of drug administration, the number of erythrocytes in the experimental animals group has increased signifi cantly (p<0.05) and after its second feeding, the positive eff ect on erythrocytopoiesis in calves has became even greater (p<0.001), compared to the calves in control group. The level of hemoglobin in calves of experimental group also increased signifi cantly from the beginning of the drug to the end of the experiment, whereas in calves of the control group there was a tendency to decrease its level throughout the all experiment. The color index and erythrocyte saturation by hemoglobin (MCH) at the fi rst and second blood samples were signifi cantly decreased (p<0.05) in control calves group, whereas in animals of experimental group there was no signifi cant diff erence between these parameters (p<0.1). The average volume of red blood cells did not diff er between control and test calves during the experiment (p<0.1). Under the drugs infl uence the Ferum blood content in calves of experimental group increased by 24.2 %. In the control calves group, this tendency was not so noticeable (the increase of Ferum serum level at the end of experiment was only +7.8 % (p<0.1), compared to the initial indices). The Zinc metabolism, on the contrary, has not undergone signifi cant changes. The Cuprum serum level in experimental calves group remained always signifi cantly higher than in control animals group. “Alphabet for Animals” has a positive eff ect on hemocytopoiesis in calves due to its complex composition (fat-soluble and water-soluble vitamins, aminoacids) and improves the metabolism of microelements, including Ferum and Cuprum. The infl uence on these processes the vitamins of B group, which are a part of this drug, we consider especially valuable in the conditions of the unformed rumen digestion in young cattle. Key words: vitamin-amino acid complex, erythrocytopoiesis, hypochromia, microcytosis, hemoglobin, color index, hematocrit.
国家维生素-氨基酸复合物对犊牛血细胞生成及微量元素代谢指标的影响
在乌克兰兽医领域,对新型复杂药物有效性的研究仍然具有重要意义。研究了“动物用字母表”复合维生素对1.5 ~ 2.5月龄犊牛血细胞生成状态和微量元素代谢的影响。该药的组成包括生物活性物质:维生素A、D3、E、B1、B3、B5、B6、B12、K3和必需氨基酸:dl -蛋氨酸、l -赖氨酸和精氨酸。用于家畜、家禽正常造血,预防和治疗维生素、微量元素代谢紊乱。在给药第一周,实验动物组的红细胞数量显著增加(p<0.05),第二次饲喂后,对犊牛红细胞生成的积极作用比对照组更大(p<0.001)。实验组犊牛血红蛋白水平从给药开始到实验结束均有显著升高,而对照组犊牛血红蛋白水平在整个实验过程中均有降低的趋势。对照犊牛第一次和第二次血液样品的颜色指数和血红蛋白红细胞饱和度(MCH)显著降低(p<0.05),试验组犊牛第一次和第二次血液样品的颜色指数和血红蛋白红细胞饱和度(MCH)差异不显著(p<0.1)。实验期间,对照犊牛和试验犊牛的红细胞平均体积无显著差异(p<0.1)。在药物作用下,试验组犊牛血清血清含量提高了24.2%。在对照犊牛组,这一趋势不那么明显(试验结束时血清Ferum水平仅比初始指标提高了7.8% (p<0.1))。相反,锌的代谢没有发生显著变化。试验犊牛血清铜水平始终显著高于对照组。“动物字母表”由于其复杂的成分(脂溶性和水溶性维生素、氨基酸),对犊牛的血细胞生成有积极的影响,并改善微量元素的代谢,包括铁和铜。该药中维生素B群对这些过程的影响,我们认为在犊牛未形成的瘤胃消化条件下特别有价值。关键词:维生素-氨基酸复合物,红细胞生成,低色素,小细胞增多,血红蛋白,显色指数,红细胞压积
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