ANTIFUNGAL AND ANTIOXIDANT ACTIVITIES OF COBALT AND NICKEL METAL COMPLEXES OF P-AMINO BENZAMIDE

Abstract

Cobalt and nickel bio-active metal chelates were synthesized using p-aminobenzamide and thiocyanate ion in an equimolar ratio, and they were assessed for conductivity, UV-Visible, IR, and far-IR spectra as well as metal ion estimation identification. Based on their spectral and magnetic characteristics, the complexes were given octahedral geometry. The complexes are paramagnetic, monomeric, and non-electrolyte. With the help of the Agar Disc diffusion method using fluconazole as the reference drug, the antifungal activity of metal chelates through an in-vitro mechanism was compared with p-aminobenzamide against C. albicans. Metal(II) chelates' in-vitro DPPH free radical scavenging ability was tested and contrasted with that of standard ascorbic acid. The complexes appear to have moderate activity, according to the results of the computation of the IC50 values at four distinct concentrations.