ANTIOXIDANT ACTIVITY OF N-HEXANE, DICHLOROMETHANE, ETHYL ACETATE, AND METHANOL EXTRACTS OF Litsea cubeba Lour. BARKS

IF 0.5 Q4 EDUCATION & EDUCATIONAL RESEARCH

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI:10.31788/rjc.2023.1628238

A. Dalimunthe, M. Muhammad, M. Rafi, V. M. Syafma, F. Hulwani, I. Aprilliawati, D. Satria

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引用次数: 1

Abstract

Free radicals are molecules with unstable unpaired electrons and originate from environmental pollutants and from unhealthy people's lifestyles that reduce the quality of life in the presence of various degenerative diseases from premature aging, stroke, and even cancer. Antioxidants are used to neutralize, reduce and inhibit the formation of new free radicals in the body by becoming electron donors for free radicals so that free electrons in free radicals become paired and stop damage in the body. With the presence of antioxidant compounds, oxidative stress triggered by free radicals can be stabilized and neutralized to reduce the risk of damage to body cells. Indonesia is a country rich in spice plant resources. One type of spice plant that has the potential to be developed is Attarasa (Litsea cubeba Lour.) which is widely found in the North Tapanuli area. This plant contains essential oils in the fruit, stems, roots, and leaves. This makes all parts of this plant smell good. This study aimed to determine the antioxidant activity of a fraction of Litsea cubeba Lour. barks. The fraction with n-hexane, dichloromethane, ethyl acetate, and methanol as solvent. Antioxidant activities were determined with ABTS, CUPRAC, and O-Phenanthroline method. The data were analyzed using the Principle Component Analysis (PCA) multivariate exploration technique, which was analyzed using the Minitab software. The extracts were obtained IC50 values from the ABTS (395.65 ± 0.37; 344.78 ± 0.57; 30.37 ± 0.04; 283.07 ± 0.85); CUPRAC (220.77 ± 0.21; 144.50 ± 0.26; 10.00 ± 0.01; 11.13 ± 0.04); O-Phenanthroline (798.27 ± 0.06; 410.01 ± 0.23; 175.75 ± 0.25; 32.01 ± 0.03) respectively. While the total phenol was analyzed (23.56 ± 0.56; 2.63 ± 0.01; 77.44 ± 0.56; 600.21 ± 0.54) respectively. Based on the results obtained, the ethyl acetate extract of Litsea cubeba Lour. barks have antioxidant activity with a very strong category.

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山苍子正己烷、二氯甲烷、乙酸乙酯和甲醇提取物的抗氧化活性。叫

自由基是具有不稳定的未成对电子的分子，来源于环境污染物和不健康的人们的生活方式，这些生活方式会降低生活质量，导致早衰、中风甚至癌症等各种退行性疾病。抗氧化剂通过成为自由基的电子供体来中和、减少和抑制体内新自由基的形成，从而使自由基中的自由电子配对并阻止体内的损害。由于抗氧化化合物的存在，自由基引发的氧化应激可以被稳定和中和，以减少对身体细胞的损害风险。印度尼西亚是一个香料植物资源丰富的国家。一种具有开发潜力的香料植物是Attarasa (Litsea cubeba Lour.)，它广泛存在于北Tapanuli地区。这种植物的果实、茎、根和叶中都含有精油。这使得这种植物的所有部分闻起来都很好。本研究旨在测定山苍子提取物的抗氧化活性。吠叫。以正己烷、二氯甲烷、乙酸乙酯和甲醇为溶剂的馏分。用ABTS法、CUPRAC法和邻菲罗啉法测定其抗氧化活性。数据分析采用主成分分析(PCA)多元探索技术，并使用Minitab软件进行分析。提取液的IC50值为(395.65±0.37;344.78±0.57;30.37±0.04;283.07±0.85);铜(220.77±0.21);144.50±0.26;10.00±0.01;11.13±0.04);邻菲罗啉(798.27±0.06;410.01±0.23;175.75±0.25;32.01±0.03)。总酚含量为(23.56±0.56;2.63±0.01;77.44±0.56;(600.21±0.54)。在此基础上，对山苍子的乙酸乙酯提取物进行了研究。树皮类具有很强的抗氧化活性。

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来源期刊

Rasayan Journal of Chemistry Energy-Energy (all)

CiteScore

1.90

自引率

0.00%

发文量

196

期刊介绍： RASĀYAN Journal of Chemistry [RJC] signifies a confluence of diverse streams of chemistry to stir up the cerebral powers of its contributors and readers. By introducing the journal by this name, we humbly intent to provide an open platform to all researchers, academicians and readers to showcase their ideas and research findings among the people of their own fraternity and to share their vast repository of knowledge and information. The journal seeks to embody the spirit of enquiry and innovation to augment the richness of existing chemistry literature and theories. We also aim towards making this journal an unparalleled reservoir of information and in process aspire to inculcate and expand the research aptitude.