OPTIMIZATION SYNTHESIS OF ZINC OXIDE NANOPARTICLES USING FACTORIAL DESIGN AND ITS ANTIBACTERIAL ACTIVITY

IF 0.5 Q4 EDUCATION & EDUCATIONAL RESEARCH

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI:10.31788/rjc.2023.1628213

N.C. Endriyatno, E.R. Wikantyasning, P. Indrayudha

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引用次数: 0

Abstract

Due to their chemical stability, potent antibacterial activity, and comparatively low hazardous profile, inorganic metal oxides may be used as efficient antibacterial. Zinc oxide nanoparticles (ZnO NPs) significantly slow down the growth of various bacteria. This study aimed to determine the effect and interaction of pH, calcination temperature, and pectin (capping agent) on the synthesis and antibacterial activity of ZnO NPs. The synthesis was carried out by the precipitation method. Synthesis optimization using Design Expert software (factorial design) with parameters including yield, particle size, polydispersity index, zeta potential, particle shape, and inhibition zone of bacteria (P.acnes, S.aureus, and S.epidermidis). This study proves that the synthesis of ZnO NPs is influenced by pH, calcination temperature, and pectin. Various characteristics of the synthesized ZnO NPs have different antibacterial activity. The results of Design Expert analysis with 3 g of precursor obtained the optimum combination at pH 8.8, calcination temperature of 600°C, and pectin 0.76%.

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利用析因设计优化氧化锌纳米颗粒的合成及其抑菌活性

无机金属氧化物具有化学稳定性好、抗菌活性强、危害小等特点，可作为高效的抗菌材料。氧化锌纳米颗粒(ZnO NPs)显著减缓了各种细菌的生长。本研究旨在研究pH、煅烧温度和果胶(封盖剂)对ZnO NPs合成和抗菌活性的影响及其相互作用。采用沉淀法合成。利用Design Expert软件进行合成优化(因子设计)，参数包括产率、粒度、多分散性指数、zeta电位、颗粒形状和细菌(p.a acnes、s.a aureus和s.a eculmidis)的抑菌区。本研究证明ZnO纳米粒子的合成受pH、煅烧温度和果胶的影响。合成的氧化锌NPs的不同特性具有不同的抗菌活性。Design Expert分析结果表明，在3 g前驱体条件下，最佳配比为pH 8.8，煅烧温度600℃，果胶0.76%。

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来源期刊

Rasayan Journal of Chemistry Energy-Energy (all)

CiteScore

1.90

自引率

0.00%

发文量

196

期刊介绍： RASĀYAN Journal of Chemistry [RJC] signifies a confluence of diverse streams of chemistry to stir up the cerebral powers of its contributors and readers. By introducing the journal by this name, we humbly intent to provide an open platform to all researchers, academicians and readers to showcase their ideas and research findings among the people of their own fraternity and to share their vast repository of knowledge and information. The journal seeks to embody the spirit of enquiry and innovation to augment the richness of existing chemistry literature and theories. We also aim towards making this journal an unparalleled reservoir of information and in process aspire to inculcate and expand the research aptitude.