DESIGN, SYNTHESIS, AND PHARMACOLOGICAL EVALUATION OF NOVEL BIS-INTERCALATORS AS POSSIBLE ANTICANCER AGENTS

Abstract

An attempt is made to design, synthesize and pharmacologically evaluate novel bis-intercalators as possible anticancer agents. According to a literature study on bis-intercalators, 4-substituted bis-benzamides are widely recognized for their medicinal uses and may be effective anticancer and antioxidant agents. Synthetic studies revealed that the yield of Chain linkers L1-L14, 4-substituted bis benzamides, and L-proline derivatives were in the 50-70% range. The 4-substituted bis benzamides compounds have been evaluated for anticancer and antioxidant activity studies. Among the 4-substituted bis benzamides compounds, Compound IIIc, IIIf, and IIIg have revealed promising anticancer and antioxidant activity. Compounds III7 and III12 have good cytotoxicity and antioxidant activity among L-proline derivatives. As a result, the current study emphasizes the significance of 4-substituted bis benzamides and L-proline derivatives with various heterocyclic moiety features responsible for cytotoxicity and antioxidant activity. It might be a starting point for further alterations to create new entities with therapeutically useful properties.