SYNTHETIC STUDY OF Pc-2, AN ACTIVE COMPOUND FROM INDONESIAN RED BETEL LEAF

IF 0.5 Q4 EDUCATION & EDUCATIONAL RESEARCH

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI:10.31788/rjc.2023.1617052

Ritmaleni, Dong-Hwi Kim

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引用次数: 0

Abstract

PC-2 is one of the active compounds isolated from Indonesian red betel leaf. The structure of the compound is named 2-allyl-4-(1'-hydroxy-1'-(3",4",5"-trimethoxyphenyl)propan-2'-yl)-3,5-dimethoxycyclohexa-3,5-dienone and included in the neolignan’s structure category. This compound was reported to have very good biological activity in giving antiproliferative effects on human breast (T47D) cells. From 2.12 g of its leaf methanolic extract, only 12.1 mg of Pc-2 was collected. This amount is too small to do more studies about its biological activities. The synthetic work should be applied to get a sufficient amount. This paper is aimed to explain the synthetic study and design of the Pc2 compound. The first approach is by involving the aldol reaction in the synthetic pathway through the disconnection approach. The result showed that this attempt did not work very well. The second approach is to design the new synthetic pathway by using the synthia Organic Retrosynthesis Software by Merck. This software gave a reasonable result to be tried. The result proposed the use of the Suzuki coupling reaction for the new synthetic pathway of Pc-2.

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印尼红槟榔叶活性化合物Pc-2的合成研究

PC-2是从印尼红槟榔叶中分离得到的活性化合物之一。该化合物的结构被命名为2-烯丙基-4-(1'-羟基-1'-(3 '，4 '，5 '-三甲氧基苯基)丙烷-2'-基)-3,5-二甲氧基环己-3,5-二烯酮，属于新木质素的结构类别。据报道，该化合物对人乳腺(T47D)细胞具有很好的抗增殖作用。从2.12 g的叶甲醇提取物中，只收集到12.1 mg的Pc-2。这个量太小，不足以对其生物活性进行更多的研究。应施加合成功以获得足够的量。本文旨在阐述Pc2化合物的合成研究和设计。第一种方法是通过断开方法将醛醇反应纳入合成途径。结果表明，这种尝试效果不太好。第二种方法是利用默克公司的synthia有机反合成软件设计新的合成途径。该软件给出了合理的测试结果。该结果提出了利用Suzuki偶联反应合成Pc-2的新途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Rasayan Journal of Chemistry Energy-Energy (all)

CiteScore

1.90

自引率

0.00%

发文量

196

期刊介绍： RASĀYAN Journal of Chemistry [RJC] signifies a confluence of diverse streams of chemistry to stir up the cerebral powers of its contributors and readers. By introducing the journal by this name, we humbly intent to provide an open platform to all researchers, academicians and readers to showcase their ideas and research findings among the people of their own fraternity and to share their vast repository of knowledge and information. The journal seeks to embody the spirit of enquiry and innovation to augment the richness of existing chemistry literature and theories. We also aim towards making this journal an unparalleled reservoir of information and in process aspire to inculcate and expand the research aptitude.