A Triad Study in South Indian Population of Telangana: On the Association of Cytokine Gene Polymorphisms in the Aetiology of Spontaneous Abortions

Obstetrics and gynecology research Pub Date : 2021-01-01 DOI:10.26502/ogr071

Renjini Devi MR, Shehnaz Sultana, V. M, Rambabu Sp, P. Nallari, Venkateshwari A

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Abstract

Background: Spontaneous abortion is defined as the loss of two or more consecutive pregnancies before 20 week of gestation. About 50% of the cases are remained with unexplained etiology. Potential immune cell differentiation and cytokine profile is detrimental for fetal-maternal communication and maternal recognition of pregnancy. An imbalance in the immune modulatory profile results in consecutive loss of pregnancies. In view of the above, the present study is taken up to understand the role of immunemodulators and their gene polymorphism in the etiology of spontaneous abortion. Methods: In the present case-control triad study genotyping for IFN γ+874 T/A, IL6-137 G/C, IL18174G/C polymorphisms were done by Amplified Refractory Mutation System polymerase chain reaction method (ARMS-PCR) and statistically analyzed. Result: A retrospective analysis for association of gene polymorphisms in the present study showed that Obstet Gynecol Res 2021; 4 (4): 220-232 DOI: 10.26502/ogr071 Obstetrics and Gynecology Research Vol. 4 No. 4– December 2021. 221 maternal and fetal TT genotype of IFN γ+874 polymorphism showed a twofold increased risk (OR 2.22, 95%CI= 1.29-3.84, p=0.004) whereas in IL 18 174G/C gene polymorphism and their association study, the case mother subjects that represented CC genotypes contributed a onefold increased risk towards the development of spontaneous abortion. (OR -2.17, 95%CI1.250-3.788, p=0.005) Conclusion: The proinflammatory and anti-inflammatory gene polymorphisms may contribute towards the susceptibility for spontaneous abortion.

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南印度特伦甘纳人口的三合一研究:细胞因子基因多态性与自然流产病因的关系

背景:自然流产是指在妊娠20周之前连续两次或两次以上流产。约50%的病例病因不明。潜在的免疫细胞分化和细胞因子谱不利于胎儿与母体的沟通和母体对妊娠的识别。免疫调节谱的不平衡导致连续流产。鉴于上述，本研究旨在了解免疫调节剂及其基因多态性在自然流产病因学中的作用。方法:采用扩增难解突变系统聚合酶链反应法(ARMS-PCR)对IFN γ+874 T/A、IL6-137 G/C、IL18174G/C多态性进行基因分型，并进行统计学分析。结果:对本研究中基因多态性相关性的回顾性分析显示，《妇产科杂志》2021;4 (4): 220-232 DOI: 10.26502/ogr071妇产科研究卷4 No. 4 - 2021年12月。221母胎TT基因型IFN γ+874多态性增加了2倍的风险(OR 2.22, 95%CI= 1.29-3.84, p=0.004)，而在IL 18 174G/C基因多态性及其相关性研究中，CC基因型的病例母亲受试者发生自然流产的风险增加了1倍。(OR -2.17, 95%CI1.250-3.788, p=0.005)结论:促炎和抗炎基因多态性可能与自然流产易感性有关。

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Obstetrics and gynecology research

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