Seroprevalence of Hepatitis E Virus (HEV) Antibodies in Human Populations of Sokodé, Togo

Komi Victor-Mari Setondji, K. A. Traore, J. Ouoba, E. Taale, B. Ouoba, Bissah Kokou Nyakou, P. Roques, Simplice Damintoti Karou, N. Barro
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Abstract

Background: Hepatitis E virus (HEV) antibodies prevalence is reported globally worldwide. However, there is still some countries where data are not well reported or even studied as in Togo. The aim of this study was to evaluate the seroprevalence of HEV among human populations and analyze demographic variables related to the infection in the city of Sokodé, in central area of Togo. Results: A total of 289 individuals including 195 blood donors (24 women and 171 men), and 94 pregnant women were recruited from May to October 2020 and socio-economic status were assessed. All obtained sera were tested for the presence of anti-HEV antibodies with the immunochromatography test (MP Diagnostics ASSURE IgM Rapid test) and the MP Diagnostics HEV-IgM and HEV-IgG ELISA. The association between anti-HEV status and potential risk factors was assessed. Total HEV antibodies were in 5.6% (95% CI: 3.8 - 7.3%) of all samples. HEV IgM antibodies were detected in 11.7% (95% CI: 9.8-13.5%) of the samples, of which 29 (14.8%) were from the blood donors group and 5 (5.3%) from pregnant women group. Gender, water storage container, type of latrine used and washing hands after toilet were associated to anti-HEV IgM seropositivity in population. (p ≤ 0.05). Conclusion: These �ndings from asymptomatic population suggest a probable HEV circulation at signi�cant levels. These data are the �rst step to understand the epidemiology of the HEV infection in Togo that deserved to be extended both in timing and Togo’s region.
多哥索科尔多瓦人群戊型肝炎病毒(HEV)抗体的血清阳性率
背景:戊型肝炎病毒(HEV)抗体在全球范围内流行。然而,仍有一些国家的数据没有得到很好的报告,甚至没有像多哥那样得到很好的研究。本研究的目的是评估多哥中部地区索科尔多瓦市人群中HEV的血清患病率,并分析与感染相关的人口统计学变量。结果:2020年5 - 10月共招募了289人,其中献血者195人(女性24人,男性171人),孕妇94人,并对社会经济状况进行了评估。用免疫层析法(MP Diagnostics ASSURE IgM快速试验)和MP Diagnostics HEV-IgM和HEV-IgG ELISA检测所有获得的血清是否存在抗hev抗体。评估抗hev状态与潜在危险因素之间的关系。所有样本中有5.6% (95% CI: 3.8 - 7.3%)存在HEV抗体。11.7% (95% CI: 9.8-13.5%)的样本中检测到HEV IgM抗体,其中29例(14.8%)来自献血者组,5例(5.3%)来自孕妇组。人群中性别、储水容器、使用的厕所类型和如厕后洗手与抗hev IgM血清阳性相关。(p≤0.05)。结论:这些来自无症状人群的结果提示可能存在显著水平的HEV循环。这些数据是了解多哥HEV感染流行病学的第一步,值得在时间和多哥地区进行扩展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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