Sequencing or not sequencing

Q2 Agricultural and Biological Sciences
J. Gu
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引用次数: 4

Abstract

Technology has been playing a very important role in the advancement of science, and big breakthroughs in science are dependent upon technologies available from time to time. Between science and technology, a good understanding is required so that available technologies can be used most efficiently and effectively to solving the targeted questions in scientific research. Genome nucleotide sequencing as an available technology after several generations of the technical improvement is capable of extract the full nucleotide sequences of any single organism or a mixed population of organisms in a given sample. This technology has a major important role in medicine and health science for diagnosis of the microorganisms and early detection of genetic diseases. In microbial ecology and applied microbiology, it is now fashionable to sequence the microbial community, the microbiome, so that the community composition and diversity are described from air, soil, water, sludge to skin and gut of animals, including humans. This routine practice, too frequently used by far too many, neither provide any significant insights of knowledge nor unravel the fundamental science in any way, but it serves as a cosmetic decoration for publication mostly. Because of this, not sequencing or sequencing less is the view expressed here to alert researchers for a better focus on the research questions, and the selection and implementation of the necessary physical science methods to obtain the solid research data that can advance science in a significant way. Publication driven experiments to produce more papers are eroding the essence of science, especially the pure spirit of science.
测序还是不测序
技术在科学的进步中一直扮演着非常重要的角色,科学的重大突破依赖于不时出现的技术。在科学和技术之间,需要有一个很好的理解,这样才能最有效地利用现有的技术来解决科学研究中的目标问题。基因组核苷酸测序作为一项经过几代技术改进的可用技术,能够提取给定样品中任何单一生物或混合生物群体的完整核苷酸序列。该技术在医学和健康科学中对微生物的诊断和遗传疾病的早期发现具有重要的作用。在微生物生态学和应用微生物学中,对微生物群落(微生物组)进行测序,以描述从空气、土壤、水、污泥到动物(包括人类)的皮肤和肠道的微生物群落组成和多样性。这种常规的做法,被太多的人过于频繁地使用,既没有提供任何重要的知识见解,也没有以任何方式揭示基础科学,但它主要是作为出版物的装饰。正因为如此,不测序或少测序是这里表达的观点,提醒研究人员更好地关注研究问题,选择和实施必要的物理科学方法,以获得可以显著推进科学的坚实研究数据。以发表论文为目的的实验正在侵蚀科学的本质,尤其是纯粹的科学精神。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Applied Environmental Biotechnology
Applied Environmental Biotechnology Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)
CiteScore
3.70
自引率
0.00%
发文量
2
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