Prevalence of HIV-associated neurocognitive disorder (HAND) and its subgroups among HIV-positive persons on anti-retroviral therapy in Iran

IF 0.9 4区心理学 Q3 PSYCHOLOGY, MULTIDISCIPLINARY

Psihologija Pub Date : 2020-01-01 DOI:10.2298/psi190414001m

Elham Mazaheri-tehrani, V. Nejati, A. Seyed, O. Dadras, A. Cossarizza, C. Mussini, Nasab Ahsani Sara, L. Sadeghi, M. Gholami, Hanieh Golchehregan, M. Mohraz

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引用次数: 6

Abstract

This study aimed to determine the prevalence and determinants of HIV-associated neurocognitive disorder (HAND) and its subgroups in HIV-positive patients in Tehran, Iran. Ninety-three HIV-positive individuals were assessed; the majority were male (60%) and the mean age of patients was 36.5 years (SD = 9), with 8 years as the median duration of HIV infection. The relationship between demographic and clinical variables was examined using logistic regression analysis. The overall prevalences of HAND and cognitive complaints were 50.5% and 73%, respectively. Lower nadir CD4 counts (? 200), lower educational levels (? 12 years), longer disease duration (? 5years), and higher depression rates were positively associated with the presence of HAND. This study shows that the prevalence of HANDs in Iran is high, but similar to the prevalence levels found in Western societies. Further studies are needed to longitudinally evaluate the presence of HAND, in particularly to recognize new biomarkers and specific neurocognitive domains in HIV.

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在伊朗接受抗逆转录病毒治疗的艾滋病毒阳性人群中，艾滋病毒相关神经认知障碍(HAND)及其亚群的患病率

本研究旨在确定伊朗德黑兰hiv阳性患者中hiv相关神经认知障碍(HAND)及其亚群的患病率和决定因素。对93名hiv阳性个体进行了评估;男性居多(60%)，患者平均年龄36.5岁(SD = 9)，中位HIV感染持续时间为8年。采用logistic回归分析检验人口学和临床变量之间的关系。HAND和认知疾病的总体患病率分别为50.5%和73%。较低的最低点CD4计数(?200)，较低的教育水平(?12年)，病程更长(?5年)，较高的抑郁率与HAND的存在呈正相关。这项研究表明，HANDs在伊朗的患病率很高，但与西方社会的患病率相似。需要进一步的研究来纵向评估HAND的存在，特别是在HIV中识别新的生物标志物和特定的神经认知域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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