Flavonoid derivatives as anticancer moiety and its effect on cancer cell lines: An updated review

IF 1 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Journal of The Serbian Chemical Society Pub Date : 2023-01-01 DOI:10.2298/jsc221228041m

C. Manojmouli, T. Pasha, K. Nagaprashant, B. Ramesh, Eain Ul, K. Purushotham

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引用次数: 0

Abstract

Cancer is now considered the number one leading cause of premature death in industrialized countries. Chemotherapy drugs are quite expensive and cause multiple side effects. Natural products have been studied in depth for their potential as anticancer agents because of their remarkable chemical variability. Among the various natural metabolites, flavonoids are secondary metabolites that are extensively present in nature, have potent anti-cancer properties, have few adverse effects, and also show synergistic benefits. Numerous laboratories are diligently investigating the chemistry and biology of novel flavonoid derivatives due to the demand for and worth of these drugs. In this review, we summarized clinical trials of various flavonoids, molecular pathways against various cancer cell lines, and recent updates on the anticancer activity of flavonoid derivatives against various cancer cells synthesized by various methods, more studies are needed to develop the following mentioned flavonoid derivatives as an anticancer drug.

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类黄酮衍生物的抗癌作用及其对癌细胞的作用:最新进展

癌症现在被认为是工业化国家过早死亡的头号原因。化疗药物非常昂贵，而且会产生多种副作用。由于天然产物具有显著的化学变异性，人们对其作为抗癌剂的潜力进行了深入研究。在多种天然代谢物中，黄酮类化合物是次生代谢物，广泛存在于自然界中，具有较强的抗癌作用，副作用少，且具有协同效应。由于对这些药物的需求和价值，许多实验室正在努力研究新型类黄酮衍生物的化学和生物学。本文综述了各类黄酮类化合物的临床试验、抗多种癌细胞的分子途径，以及通过各种方法合成的类黄酮衍生物抗多种癌细胞活性的最新进展，指出以下类黄酮衍生物作为抗癌药物有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of The Serbian Chemical Society 化学-化学综合

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of the Serbian Chemical Society -JSCS (formerly Glasnik Hemijskog društva Beograd) publishes articles original papers that have not been published previously, from the fields of fundamental and applied chemistry: Theoretical Chemistry, Organic Chemistry, Biochemistry and Biotechnology, Food Chemistry, Technology and Engineering, Inorganic Chemistry, Polymers, Analytical Chemistry, Physical Chemistry, Spectroscopy, Electrochemistry, Thermodynamics, Chemical Engineering, Textile Engineering, Materials, Ceramics, Metallurgy, Geochemistry, Environmental Chemistry, History of and Education in Chemistry.