Use of aliphatic thiols for on-site derivatization and gas chromatographic identification of Adamsite

Abstract

The report describes the development of methods for rapid and simple identification of Adamsite in mobile laboratory conditions using a field gas chromatograph coupled with mass spectrometer. Adamsite is a chemical warfare agent with unique properties that cannot be analyzed without conversion to a volatile derivative. Derivatization procedures with 5 aliphatic thiols (ethanethiol, 1-propanethiol, 2-propanethiol, 1-butanethiol and 1-hexanethiol) were developed and compared. The retention characteristics of the derivatization products, peak characteristics and the formation of unwanted artifacts in the chromatograms were monitored. The influence of the reaction media and the time dependence of the reaction were also objects of interest. Other investigated parameters were the optimal reaction temperature and the volume of the derivatization agent. Mass spectra of newly created substances that are not yet included in the chemical weapons related databases were recorded. With optimal reagents (1-butanethiol and 1-hexanethiol), calibration procedures for analyte determination were subsequently developed, and the methods were verified during the Adamsite identification test in selected environmental and urban matrices.