Advances in diagnosis, clinical care, research, and treatment in retinopathy of prematurity

IF 3.1 Q1 OPHTHALMOLOGY

Eye and Brain Pub Date : 2016-05-19 DOI:10.2147/EB.S105319

Drs Patricia D’Amore, K. Connor, Drs Cynthia Toth

引用次数: 5

Abstract

The appearance of retinopathy of prematurity (ROP) has changed throughout the world and since the first description of “retrolental fibroplasia” in 1942. However, despite advances in neonatal care and the abilities to improve the survival of ever younger and smaller premature infants, ROP remains a leading cause of childhood blindness worldwide. We know that ROP is complex in that it is influenced by genetic predisposition, epigenetic regulation, and environmental risks. It is strongly associated with extreme degrees of prematurity, and the “phenotype” of ROP depends on resources available to support premature infants with adequate nutrition and regulation of oxygen, as examples. New studies also suggest that what is seen in the preterm infant retina may portend later neurodevelopmental outcomes. Therefore, we believe this is a needed time to revisit ROP and provide a thematic issue focused on ROP from several perspectives.

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早产儿视网膜病变的诊断、临床护理、研究和治疗进展

自1942年首次描述“视网膜后纤维增生”以来，早产儿视网膜病变(ROP)的外观在世界范围内发生了变化。然而，尽管在新生儿护理方面取得了进步，并且有能力提高更小和更小的早产儿的存活率，ROP仍然是世界范围内儿童失明的主要原因。我们知道ROP是复杂的，因为它受到遗传易感性、表观遗传调控和环境风险的影响。它与极端程度的早产密切相关，例如，ROP的“表型”取决于为早产儿提供充足营养和氧气调节的可用资源。新的研究还表明，在早产儿视网膜上所看到的可能预示着后来的神经发育结果。因此，我们认为现在是重新审视机械钻速的必要时机，并从几个角度提供一个专注于机械钻速的专题问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eye and Brain OPHTHALMOLOGY-

CiteScore

7.90

自引率

2.30%

发文量

审稿时长

16 weeks

期刊介绍： Eye and Brain is an international, peer-reviewed, open access journal focusing on basic research, clinical findings, and expert reviews in the field of visual science and neuro-ophthalmology. The journal’s unique focus is the link between two well-known visual centres, the eye and the brain, with an emphasis on the importance of such connections. All aspects of clinical and especially basic research on the visual system are addressed within the journal as well as significant future directions in vision research and therapeutic measures. This unique journal focuses on neurological aspects of vision – both physiological and pathological. The scope of the journal spans from the cornea to the associational visual cortex and all the visual centers in between. Topics range from basic biological mechanisms to therapeutic treatment, from simple organisms to humans, and utilizing techniques from molecular biology to behavior. The journal especially welcomes primary research articles or review papers that make the connection between the eye and the brain. Specific areas covered in the journal include: Physiology and pathophysiology of visual centers, Eye movement disorders and strabismus, Cellular, biochemical, and molecular features of the visual system, Structural and functional organization of the eye and of the visual cortex, Metabolic demands of the visual system, Diseases and disorders with neuro-ophthalmic manifestations, Clinical and experimental neuro-ophthalmology and visual system pathologies, Epidemiological studies.