The Versatility of Two-Dimensional Liquid Chromatography

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Brazilian Chemical Society Pub Date : 2023-10-23 DOI:10.21577/0103-5053.20230118

Carmen Cardoso, M. D. de Moraes, Q. Cass

引用次数: 1

Abstract

This review deals with two-dimensional liquid chromatography (2D-LC) separations encompassing target heart-cut (LC-LC), multiple heart-cut (mLC-LC), non-targeted comprehensive (LC × LC), and selective comprehensive (sLC × LC) analysis. It presents an overview of basic concepts and emphasizes the versatility of the applications gained by going from one-(1D) to two-dimensional (2D) separations. This review also discusses target analysis of achiral and chiral drugs for different applications and the use of 2D-LC in zonal bioaffinity chromatography. Advances in instrumental and column technologies have widened the application of LC × LC and sLC × LC separations, and we will discuss some of them.

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二维液相色谱的多功能性

本文综述了二维液相色谱(2D-LC)分离方法，包括目标心脏切割(LC-LC)、多重心脏切割(mLC-LC)、非靶向综合(LC × LC)和选择性综合(sLC × LC)分析。它提出了基本概念的概述，并强调从一(1D)到二维(2D)分离获得的应用的多功能性。本文还讨论了非手性和手性药物的不同用途的靶分析以及2D-LC在区域生物亲和色谱中的应用。仪器技术和色谱柱技术的进步扩大了LC × LC和sLC × LC分离的应用范围，我们将讨论其中的一些方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Brazilian Chemical Society 化学-化学综合

CiteScore

2.90

自引率

7.10%

发文量

审稿时长

3.4 months

期刊介绍： The Journal of the Brazilian Chemical Society embraces all aspects of chemistry except education, philosophy and history of chemistry. It is a medium for reporting selected original and significant contributions to new chemical knowledge.