ASSOCIATION BETWEEN CARBAMAZEPINE INDUCED SEVERE CUTANEOUS ADVERSE DRUG REACTION AND HLA POLIMORPHISMS

Malang Neurology Journal Pub Date : 2016-01-01 DOI:10.21776/UB.MNJ.2016.002.01.7

S. Ratnaningrum

引用次数: 0

Abstract

Carbamazepine as an antiepileptic drug that is used widely and was known can cause severe cutaneous adverse drug reactions like SJS-TEN. These adverse drug reactions is known to be associated with some specific HLA polymorphism in European populations (HLA-A*31: 01), China (HLA-A*31: 01; HLA-B*15: 02), Japan (HLA-A*31 : 01; HLA-B*15: 11), Korea HLA-A*31: 01; HLA-B*15: 02; HLA-B*15: 11), India (HLA-B*15: 02), Thailand (HLA-B*15: 02), and Malaysia (HLA-B*15: 02). Information related to certain HLA polymorphism is important to prevent adverse drug reaction but there is no sufficient data on the population of Indonesia.

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卡马西平引起的严重皮肤不良反应与hla多态性的关系

卡马西平作为一种广泛使用的抗癫痫药物，已知可引起严重的皮肤不良反应，如SJS-TEN。已知这些药物不良反应与欧洲人群(HLA- a * 31:01)、中国人群(HLA- a * 31:01;HLA-B* 15:02)，日本(HLA-A* 31:01;HLA-B* 15:11)，韩国HLA-A* 31:01;HLA-B * 15: 02;HLA-B* 15:11)、印度(HLA-B* 15:02)、泰国(HLA-B* 15:02)、马来西亚(HLA-B* 15:02)。与某些HLA多态性相关的信息对预防药物不良反应很重要，但在印度尼西亚人口中没有足够的数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Malang Neurology Journal

自引率

0.00%

发文量

审稿时长

48 weeks