THE EFFECT OF BETA GLUCAN OF SACCHAROMYCES CEREVISAE ON THE INCREASE OF THE NUMBER OF BRAIN CELLS IN SUBSTANTIA NIGRA BRAIN OF PARKINSON’S WISTAR STRAIN RAT (RATTUS NORVEGICUS) MODEL INDUCED WITH ROTENONE

Malang Neurology Journal Pub Date : 2015-01-01 DOI:10.21776/UB.MNJ.2015.001.01.4

Masruroh Rahayu, S. Kurniawan, D. Anggraini

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引用次数: 1

Abstract

Background. Beta glucan from Saccharomyces cerevisae is very potential to be used as a regenerative therapy of Parkinson's disease. Beta glucan can increase the mobilization of hematopoietic stem cells (HSCs) from the bone marrow into the damaged tissues. Objective. To find out the effects of the addition of Saccharomyces cerevisae toward the number of brain cells in substantia nigra Parkinson’s rat model. Methods. Experimental research in vivo using the draft of randomized post test only controlled group design. Results. Treatment Group 3 (72 mg/kgBB) was a group with the largest number of brain cells than the other treatment groups. Statistical data obtained showed that the average number of brain cells in negative control group was 192.00 cells; positive control amounted to 116.80 cells; Treatment 1 amounted to 135.40 cells; Treatment 2 amounted to 140.80 cells; and Treatment 3 amounted to 161.80 cells. Conclusion. The addition of Saccharomyces cerevisae with a dose of 18mg/kgBB, 36mg/kgBBdan 72mg/kgBB is able to increase the number of brain cells in the substantia nigra of the brain of Parkinson’s Strain Wistar rat model significantly.

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酒酵母葡聚糖对鱼藤酮诱导的帕金森病wistar系大鼠模型黑质脑组织细胞数量增加的影响

背景。从酿酒酵母中提取的葡聚糖很有可能用于帕金森病的再生治疗。β -葡聚糖可以增加造血干细胞(hsc)从骨髓向受损组织的动员。目标。探讨添加酿酒酵母对黑质帕金森病大鼠模型脑细胞数量的影响。方法。体内实验研究采用草稿随机后验只设对照组设计。结果。治疗3组(72 mg/kgBB)是小鼠脑细胞数量最多的治疗组。统计数据显示，阴性对照组平均脑细胞数为192.00个;阳性对照116.80个细胞;处理1共135.40个细胞;处理2为140.80个细胞;处理3共161.80个细胞。结论。添加18mg/kgBB、36mg/ kgbb和72mg/kgBB剂量的酿酒酵母可显著增加帕金森病Wistar大鼠模型脑黑质内脑细胞数量。

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Malang Neurology Journal

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审稿时长

48 weeks