Botanics: a potential source of new therapies for Alzheimer's disease?

Arif Nisha Syad, K. P. Devi
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引用次数: 27

Abstract

: Alzheimer’s disease is an age-related, complex neurodegenerative disorder characterized by loss of memory and impairment of multiple cognitive functions. Several factors contribute to the progression and development of the disease including amyloid beta accumulation, neurofibrillary tangle formation, cholinergic deficit, oxidative stress, neuroinflammation, and apoptosis. Numerous traditional and herbal medicinal plants have been used to treat several cognitive disorders including Alzheimer’s disease. They act as excellent antioxidants, anti-inflammatory mediators, and cholinesterase and β -secretase inhibitors. In addition, these natural compounds also prevent the accumulation of amyloid beta and its fibril formation. Besides acting as core-molecules, these natural compounds act as a template for the production and synthesis of several drug leads with improved pharmacokinetic potentials and greater efficacies. Hence, herbal medicines that have interesting pharmacological effects with noticeable anti-Alzheimer’s potential deserve increased attention for further development to drug entities. The present article reviews the botanical pharmacology with special reference to anti-Alzheimer activity of plants and plant-derived compounds.
植物学:阿尔茨海默病新疗法的潜在来源?
阿尔茨海默病是一种与年龄相关的复杂神经退行性疾病,其特征是记忆丧失和多种认知功能受损。多种因素导致疾病的进展和发展,包括淀粉样蛋白积累、神经原纤维缠结形成、胆碱能缺陷、氧化应激、神经炎症和细胞凋亡。许多传统和草药植物已被用于治疗包括阿尔茨海默病在内的几种认知障碍。它们是极好的抗氧化剂,抗炎介质,以及胆碱酯酶和β分泌酶抑制剂。此外,这些天然化合物还能防止淀粉样蛋白的积累及其纤维的形成。除了作为核心分子外,这些天然化合物还作为几种药物先导物的生产和合成模板,具有更好的药代动力学电位和更高的功效。因此,具有显著抗阿尔茨海默病潜力的有趣药理作用的草药值得进一步关注,以进一步开发药物实体。本文综述了植物药理学的研究进展,重点介绍了植物及其衍生化合物的抗阿尔茨海默病活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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