A systematic updated review of scientifically tested selected plants used for anxiety disorders

Botanics : targets and therapy Pub Date : 2012-09-07 DOI:10.2147/BTAT.S20593

Ashutosh Sharma, Alexandre Cardoso-Taketa, G. García, M. Villarreal

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The information gathered on plants with attributed anxiolytic properties are presented as follows: (1) plant extracts with anxiolytic properties evaluated in animal models; (2) plants with clinical trials; (3) identi- fied active compounds in plants that have been assayed in animal models; (4) mechanism of action of anxiolytic plant extracts and compounds; and (5) registered patents for anxiolytic plant preparations. We recorded 112 plant species belonging to 63 botanical families for which the anxiolytic properties had been tested in animal models. Eleven plant species to treat general anxiety disorders as well as eleven species to treat anxiety-associated conditions, had been documented by clinical trials. Thirty-three registers for active compounds belonging to five general types of secondary metabolites had also been recorded. The mechanism of action at the central nervous system level had been determined in 33 plant species, either in their extracts or isolated compounds. Forty-seven patent registrations for plant preparations to be used for the treatment of anxiety were included. Abstract: The aim of this review is to provide a summary on multidisciplinary scientific information obtained from medicinal plants used worldwide to treat anxiety, focusing on phar- macological and clinical studies. The bibliographical investigation was carried out by consulting five peer-reviewed worldwide database publications for references, and patents. The information gathered on plants with attributed anxiolytic properties are presented as follows: (1) plant extracts with anxiolytic properties evaluated in animal models; (2) plants with clinical trials; (3) identi- fied active compounds in plants that have been assayed in animal models; (4) mechanism of action of anxiolytic plant extracts and compounds; and (5) registered patents for anxiolytic plant preparations. We recorded 112 plant species belonging to 63 botanical families for which the anxiolytic properties had been tested in animal models. Eleven plant species to treat general anxiety disorders as well as eleven species to treat anxiety-associated conditions, had been documented by clinical trials. Thirty-three registers for active compounds belonging to five general types of secondary metabolites had also been recorded. The mechanism of action at the central nervous system level had been determined in 33 plant species, either in their extracts or isolated compounds. Forty-seven patent registrations for plant preparations to be used for the Abstract: The aim of this review is to provide a summary on multidisciplinary scientific information obtained from medicinal plants used worldwide to treat anxiety, focusing on phar- macological and clinical studies. The bibliographical investigation was carried out by consulting five peer-reviewed worldwide database publications for references, and patents. The information gathered on plants with attributed anxiolytic properties are presented as follows: (1) plant extracts with anxiolytic properties evaluated in animal models; (2) plants with clinical trials; (3) identi- fied active compounds in plants that have been assayed in animal models; (4) mechanism of action of anxiolytic plant extracts and compounds; and (5) registered patents for anxiolytic plant preparations. We recorded 112 plant species belonging to 63 botanical families for which the anxiolytic properties had been tested in animal models. Eleven plant species to treat general anxiety disorders as well as eleven species to treat anxiety-associated conditions, had been documented by clinical trials. Thirty-three registers for active compounds belonging to five general types of secondary metabolites had also been recorded. 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引用次数: 10

Abstract

The aim of this review is to provide a summary on multidisciplinary scientific information obtained from medicinal plants used worldwide to treat anxiety, focusing on phar- macological and clinical studies. The bibliographical investigation was carried out by consulting five peer-reviewed worldwide database publications for references, and patents. The information gathered on plants with attributed anxiolytic properties are presented as follows: (1) plant extracts with anxiolytic properties evaluated in animal models; (2) plants with clinical trials; (3) identi- fied active compounds in plants that have been assayed in animal models; (4) mechanism of action of anxiolytic plant extracts and compounds; and (5) registered patents for anxiolytic plant preparations. We recorded 112 plant species belonging to 63 botanical families for which the anxiolytic properties had been tested in animal models. Eleven plant species to treat general anxiety disorders as well as eleven species to treat anxiety-associated conditions, had been documented by clinical trials. Thirty-three registers for active compounds belonging to five general types of secondary metabolites had also been recorded. The mechanism of action at the central nervous system level had been determined in 33 plant species, either in their extracts or isolated compounds. Forty-seven patent registrations for plant preparations to be used for the treatment of anxiety were included. Abstract: The aim of this review is to provide a summary on multidisciplinary scientific information obtained from medicinal plants used worldwide to treat anxiety, focusing on phar- macological and clinical studies. The bibliographical investigation was carried out by consulting five peer-reviewed worldwide database publications for references, and patents. The information gathered on plants with attributed anxiolytic properties are presented as follows: (1) plant extracts with anxiolytic properties evaluated in animal models; (2) plants with clinical trials; (3) identi- fied active compounds in plants that have been assayed in animal models; (4) mechanism of action of anxiolytic plant extracts and compounds; and (5) registered patents for anxiolytic plant preparations. We recorded 112 plant species belonging to 63 botanical families for which the anxiolytic properties had been tested in animal models. Eleven plant species to treat general anxiety disorders as well as eleven species to treat anxiety-associated conditions, had been documented by clinical trials. Thirty-three registers for active compounds belonging to five general types of secondary metabolites had also been recorded. The mechanism of action at the central nervous system level had been determined in 33 plant species, either in their extracts or isolated compounds. Forty-seven patent registrations for plant preparations to be used for the Abstract: The aim of this review is to provide a summary on multidisciplinary scientific information obtained from medicinal plants used worldwide to treat anxiety, focusing on phar- macological and clinical studies. The bibliographical investigation was carried out by consulting five peer-reviewed worldwide database publications for references, and patents. The information gathered on plants with attributed anxiolytic properties are presented as follows: (1) plant extracts with anxiolytic properties evaluated in animal models; (2) plants with clinical trials; (3) identi- fied active compounds in plants that have been assayed in animal models; (4) mechanism of action of anxiolytic plant extracts and compounds; and (5) registered patents for anxiolytic plant preparations. We recorded 112 plant species belonging to 63 botanical families for which the anxiolytic properties had been tested in animal models. Eleven plant species to treat general anxiety disorders as well as eleven species to treat anxiety-associated conditions, had been documented by clinical trials. Thirty-three registers for active compounds belonging to five general types of secondary metabolites had also been recorded. The mechanism of action at the central nervous system level had been determined in 33 plant species, either in their extracts or isolated compounds. Forty-seven patent registrations for plant preparations to be used for the treatment of anxiety were included. Abstract The aim of the present work is to demonstrate the putative sedative and anxiolytic-like effects of a hydro-ethanolic extract obtained from the aerial parts ofAloysia polystachya(Verbenaceae) in male mice using several behavioural assays. Groups of male mice orally treated with doses of 1.0, 10.0 and 100.0mg/kg of the extract did not show any significant alteration of their locomotor activity, body temperature or motor coordination. The same treatment increased the duration of the sleeping time induced by 30.0mg/kg i.p. of sodium pentobarbital. However, the sleeping time induced by ethyl ether was not modified by the oral administration of the extract, not confirming the putative sedative effect of the plant. The ethanolicextractalsosignificantlyincreasedthepercentageofbothentries(1.0and100.0mg/kg)andthetimespent(10.0and100.0mg/kg)intothe

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一个系统的更新审查科学测试选定的植物用于焦虑症

本文从药理学和临床研究两方面综述了国内外用于治疗焦虑的药用植物的多学科研究进展。文献调查是通过咨询五个同行评议的全球数据库出版物来进行的，包括参考文献和专利。收集到的具有抗焦虑特性的植物的信息如下:(1)在动物模型中评估了抗焦虑特性的植物提取物;(二)有临床试验的植物;(3)在动物模型中鉴定出的植物活性化合物;(4)抗焦虑植物提取物及化合物的作用机制;(5)抗焦虑植物制剂注册专利。我们记录了63科112种植物，并在动物模型中测试了它们的抗焦虑性。临床试验证明，有11种植物可以治疗一般焦虑症，也有11种植物可以治疗焦虑相关疾病。还记录了属于五种一般次生代谢物类型的33种活性化合物。已经在33种植物的提取物或分离物中确定了中枢神经系统水平的作用机制。其中包括47项用于治疗焦虑的植物制剂的专利注册。摘要:本文从药理学和临床研究两方面综述了国内外用于治疗焦虑的药用植物的多学科研究进展。文献调查是通过咨询五个同行评议的全球数据库出版物来进行的，包括参考文献和专利。收集到的具有抗焦虑特性的植物的信息如下:(1)在动物模型中评估了抗焦虑特性的植物提取物;(二)有临床试验的植物;(3)在动物模型中鉴定出的植物活性化合物;(4)抗焦虑植物提取物及化合物的作用机制;(5)抗焦虑植物制剂注册专利。我们记录了63科112种植物，并在动物模型中测试了它们的抗焦虑性。临床试验证明，有11种植物可以治疗一般焦虑症，也有11种植物可以治疗焦虑相关疾病。还记录了属于五种一般次生代谢物类型的33种活性化合物。已经在33种植物的提取物或分离物中确定了中枢神经系统水平的作用机制。摘要:本文从药理学和临床研究两方面综述了世界范围内用于治疗焦虑的药用植物的多学科科学信息。文献调查是通过咨询五个同行评议的全球数据库出版物来进行的，包括参考文献和专利。收集到的具有抗焦虑特性的植物的信息如下:(1)在动物模型中评估了抗焦虑特性的植物提取物;(二)有临床试验的植物;(3)在动物模型中鉴定出的植物活性化合物;(4)抗焦虑植物提取物及化合物的作用机制;(5)抗焦虑植物制剂注册专利。我们记录了63科112种植物，并在动物模型中测试了它们的抗焦虑性。临床试验证明，有11种植物可以治疗一般焦虑症，也有11种植物可以治疗焦虑相关疾病。还记录了属于五种一般次生代谢物类型的33种活性化合物。已经在33种植物的提取物或分离物中确定了中枢神经系统水平的作用机制。其中包括47项用于治疗焦虑的植物制剂的专利注册。摘要:本研究的目的是通过几种行为分析，证明从马鞭草科(aloysia polystachya)的空中部分获得的水乙醇提取物在雄性小鼠中的镇静和抗焦虑样作用。以1.0、10.0和100.0mg/kg剂量口服的雄性小鼠各组的运动活动、体温和运动协调性均无明显变化。戊巴比妥钠剂量为30.0mg/kg / i.p.，在相同剂量下可延长睡眠时间。本文从药理学和临床研究两方面综述了国内外用于治疗焦虑的药用植物的多学科研究进展。文献调查是通过咨询五个同行评议的全球数据库出版物来进行的，包括参考文献和专利。收集到的具有抗焦虑特性的植物的信息如下:(1)在动物模型中评估了抗焦虑特性的植物提取物;(二)有临床试验的植物;(3)在动物模型中鉴定出的植物活性化合物;(4)抗焦虑植物提取物及化合物的作用机制;(5)抗焦虑植物制剂注册专利。我们记录了63科112种植物，并在动物模型中测试了它们的抗焦虑性。临床试验证明，有11种植物可以治疗一般焦虑症，也有11种植物可以治疗焦虑相关疾病。还记录了属于五种一般次生代谢物类型的33种活性化合物。已经在33种植物的提取物或分离物中确定了中枢神经系统水平的作用机制。其中包括47项用于治疗焦虑的植物制剂的专利注册。摘要:本文从药理学和临床研究两方面综述了国内外用于治疗焦虑的药用植物的多学科研究进展。文献调查是通过咨询五个同行评议的全球数据库出版物来进行的，包括参考文献和专利。收集到的具有抗焦虑特性的植物的信息如下:(1)在动物模型中评估了抗焦虑特性的植物提取物;(二)有临床试验的植物;(3)在动物模型中鉴定出的植物活性化合物;(4)抗焦虑植物提取物及化合物的作用机制;(5)抗焦虑植物制剂注册专利。我们记录了63科112种植物，并在动物模型中测试了它们的抗焦虑性。临床试验证明，有11种植物可以治疗一般焦虑症，也有11种植物可以治疗焦虑相关疾病。还记录了属于五种一般次生代谢物类型的33种活性化合物。已经在33种植物的提取物或分离物中确定了中枢神经系统水平的作用机制。摘要:本文从药理学和临床研究两方面综述了世界范围内用于治疗焦虑的药用植物的多学科科学信息。文献调查是通过咨询五个同行评议的全球数据库出版物来进行的，包括参考文献和专利。收集到的具有抗焦虑特性的植物的信息如下:(1)在动物模型中评估了抗焦虑特性的植物提取物;(二)有临床试验的植物;(3)在动物模型中鉴定出的植物活性化合物;(4)抗焦虑植物提取物及化合物的作用机制;(5)抗焦虑植物制剂注册专利。我们记录了63科112种植物，并在动物模型中测试了它们的抗焦虑性。临床试验证明，有11种植物可以治疗一般焦虑症，也有11种植物可以治疗焦虑相关疾病。还记录了属于五种一般次生代谢物类型的33种活性化合物。已经在33种植物的提取物或分离物中确定了中枢神经系统水平的作用机制。其中包括47项用于治疗焦虑的植物制剂的专利注册。摘要:本研究的目的是通过几种行为分析，证明从马鞭草科(aloysia polystachya)的空中部分获得的水乙醇提取物在雄性小鼠中的镇静和抗焦虑样作用。以1.0、10.0和100.0mg/kg剂量口服的雄性小鼠各组的运动活动、体温和运动协调性均无明显变化。戊巴比妥钠剂量为30.0mg/kg / i.p.，在相同剂量下可延长睡眠时间。然而，乙醚诱导的睡眠时间并未因口服提取物而改变，因此不证实该植物的镇静作用。ethanolicextractalsosignificantlyincreasedthepercentageofbothentries (1.0 and100.0mg /公斤)andthetimespent (10.0 and100.0mg /公斤)进入然而，乙醚诱导的睡眠时间并未因口服提取物而改变，因此不证实该植物的镇静作用。ethanolicextractalsosignificantlyincreasedthepercentageofbothentries (1.0 and100.0mg /公斤)andthetimespent (10.0 and100.0mg /公斤)进入

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Botanics : targets and therapy

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